D. C. H. BIGG

Homocamptothecin, an E-ring modified camptothecin with enhanced lactone stability, retains topoisomerase I-targeted activity and antitumor properties.

Laurence Lesueur‐Ginot, Danièle Demarquay, Róbert Kiss et al. · PubMed · 1999 · 109 citations

Medicine, Medicinal Chemistry, Pharmacology +12

Homocamptothecin, an E-ring-modified camptothecin, exerts more potent antiproliferative activity than other topoisomerase I inhibitors in human colon cancers obtained from surgery and maintained in vitro under histotypical culture conditions.

P. Philippart, Luke Harper, Carole Chaboteaux et al. · PubMed · 2000 · 44 citations

Medicine, Oncology, Pharmacology +13

Synthesis of novel isoquinoline derivatives as potential CNS‐agents

B. Bonnaud, A. Carlessi, D. C. H. BIGG · Journal of Heterocyclic Chemistry · 1993 · 34 citations

Medicine, Medicinal Chemistry, Pharmacology +17

Apoptosis Induced by the Homocamptothecin Anticancer Drug BN80915 in HL-60 Cells

Michaël Facompré, Nicole Wattez, Marie‐Paule Hildebrand et al. · Molecular Pharmacology · 2001 · 28 citations

Medicine, Oncology, Pharmacology +17

Muscarinic agonists provide a new class of acaricide

D. C. H. BIGG, S. R. PURVIS · Nature · 1976 · 24 citations

Medicine, Medicinal Chemistry, Pharmacology +7