Toshiaki Sakamoto

Discovery of Canagliflozin, a Novel <i>C</i>-Glucoside with Thiophene Ring, as Sodium-Dependent Glucose Cotransporter 2 Inhibitor for the Treatment of Type 2 Diabetes Mellitus

Sumihiro Nomura, Shigeki Sakamaki, Mitsuya Hongu et al. · Journal of Medicinal Chemistry · 2010 · 371 citations · Full text

Heteroaromatic Ring, Metabolic Syndrome, Medicinal Chemistry +15

Histone deacetylase inhibitors enhance the chemosensitivity of tumor cells with cross‐resistance to a wide range of DNA‐damaging drugs

Kei‐ichi Ozaki, Futaba Kishikawa, Masashi Tanaka et al. · Cancer Science · 2008 · 85 citations · Full text

Blockade of the ERK or PI3K–Akt signaling pathway enhances the cytotoxicity of histone deacetylase inhibitors in tumor cells resistant to gefitinib or imatinib

Kei‐ichi Ozaki, Masaki Kosugi, Nobuyuki Baba et al. · Biochemical and Biophysical Research Communications · 2009 · 46 citations · Full text

Epigenetic Regulation, Medicine, Histone Deacetylase Inhibitors +8

Condensed thienopyrimidines. II. Synthesis and gastric antisecretory activity of thiazole and polymethylene condensed thienopyrimidine derivatives.

Mitsuo Sugiyama, Toshiaki Sakamoto, Keiichi Tabata et al. · Chemical and Pharmaceutical Bulletin · 1989 · 36 citations · Full text

C-Glucosides with heteroaryl thiophene as novel sodium-dependent glucose cotransporter 2 inhibitors

Yuichi Koga, Shigeki Sakamaki, Mitsuya Hongu et al. · Bioorganic & Medicinal Chemistry · 2013 · 29 citations · Full text

Molecular Pharmacology, Heteroaryl Thiophene, Biochemistry +8