Shigeki Sakamaki

Discovery of Canagliflozin, a Novel <i>C</i>-Glucoside with Thiophene Ring, as Sodium-Dependent Glucose Cotransporter 2 Inhibitor for the Treatment of Type 2 Diabetes Mellitus

Sumihiro Nomura, Shigeki Sakamaki, Mitsuya Hongu et al. · Journal of Medicinal Chemistry · 2010 · 371 citations · Full text

Heteroaromatic Ring, Metabolic Syndrome, Medicinal Chemistry +15

Novel Indole-<i>N</i>-glucoside, TA-1887 As a Sodium Glucose Cotransporter 2 Inhibitor for Treatment of Type 2 Diabetes

Sumihiro Nomura, Yasuo Yamamoto, Yosuke Matsumura et al. · ACS Medicinal Chemistry Letters · 2013 · 52 citations · Full text

Metabolic Syndrome, Medicinal Chemistry, Selective Hsglt2 Inhibitor +13

Aryl-β-C-glucosidation using glucal boronate: application to the synthesis of tri-O-methylnorbergenin

Shigeki Sakamaki, Eiji Kawanishi, Sumihiro Nomura et al. · Tetrahedron · 2012 · 38 citations

Bioorganic Chemistry, Biochemistry, Natural Sciences +6

C-Glucosides with heteroaryl thiophene as novel sodium-dependent glucose cotransporter 2 inhibitors

Yuichi Koga, Shigeki Sakamaki, Mitsuya Hongu et al. · Bioorganic & Medicinal Chemistry · 2013 · 29 citations · Full text

Molecular Pharmacology, Heteroaryl Thiophene, Biochemistry +8

N-glucosides as human sodium-dependent glucose cotransporter 2 (hSGLT2) inhibitors

Yasuo Yamamoto, Eiji Kawanishi, Yuichi Koga et al. · Bioorganic & Medicinal Chemistry Letters · 2013 · 25 citations · Full text

Molecular Pharmacology, Diabetes Management, Biochemistry +4