Kazuo Nakai

A small molecule that binds Hedgehog and blocks its signaling in human cells

Benjamin Z. Stanton, Lee F. Peng, Nicole Maloof et al. · Nature Chemical Biology · 2009 · 285 citations · Full text

Signal Transduction, Developmental Biology, Signaling Pathway +8

A Thermodynamic Preference of Chiral <i>N</i>-Methanesulfonyl and <i>N</i>-Arenesulfonyl 2,3-<i>cis</i>-3-Alkyl-2-Vinylaziridines over Their 2,3-<i>Trans</i>-Isomers:  Useful Palladium(0)-Catalyzed Equilibration Reactions for the Synthesis of (<i>E</i>)-Alkene Dipeptide Isosteres

Toshiro Ibuka, Norio Mimura, Hiroshi Aoyama et al. · The Journal of Organic Chemistry · 1997 · 104 citations

Chemical Engineering, Engineering, -Alkene Dipeptide Isosteres +11

A Novel Route to Diastereomerically Pure (<i>E</i>)‐Alkene Dipeptide Isosteres from β‐Aziridinyl‐α,β‐enoates by Treatment with Organocopper Reagents

Toshiro Ibuka, Kazuo Nakai, Hiromu Habashita et al. · Angewandte Chemie International Edition in English · 1994 · 92 citations

Bioorganic Chemistry, Absolute Configuration, Biochemistry +12

Discovery and structural characterization of peficitinib (ASP015K) as a novel and potent JAK inhibitor

Hisao Hamaguchi, Y. Amano, Ayako Moritomo et al. · Bioorganic & Medicinal Chemistry · 2018 · 80 citations · Full text

Medicinal Chemistry, Structural Characterization, Drug Target +11

Developmental Anomalies in Offspring of Pregnant Mice Treated with Nicotine

Hideo Nishimura, Kazuo Nakai · Science · 1958 · 71 citations

Knockout Mouse, Tobacco Control, Developmental Biology +9