Stephen J. Shuttleworth

The Identification of 2-(1<i>H</i>-Indazol-4-yl)-6-(4-methanesulfonyl-piperazin-1-ylmethyl)-4-morpholin-4-yl-thieno[3,2-<i>d</i>]pyrimidine (GDC-0941) as a Potent, Selective, Orally Bioavailable Inhibitor of Class I PI3 Kinase for the Treatment of Cancer

Adrian Folkes, Khatereh Ahmadi, W. Alderton et al. · Journal of Medicinal Chemistry · 2008 · 746 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +13

Exploring the specificity of the PI3K family inhibitor LY294002

Severine Gharbi, Marketa Zvelebil, Stephen J. Shuttleworth et al. · Biochemical Journal · 2007 · 464 citations · Full text

Life Sciences, Oncology, Pharmacology +15

Functionalised Polymers: Recent Developments and New Applications in Synthetic Organic Chemistry

Stephen J. Shuttleworth, Steven M. Allin, Pradeep K. Sharma · Synthesis · 1997 · 250 citations

Natural Sciences, Chemical Engineering, Chemistry +13

Functionalised Polymers in Organic Chemistry; Part 2

Stephen J. Shuttleworth, Steven M. Allin, Richard D. Wilson et al. · Synthesis · 2000 · 151 citations

Natural Sciences, Chemical Engineering, Chemistry +17

Compensation between CSF1R+ macrophages and Foxp3+ Treg cells drives resistance to tumor immunotherapy

Dávid Győri, Ee Lyn Lim, Francis M. Grant et al. · JCI Insight · 2018 · 143 citations · Full text

Life Sciences, Immunology, Oncology +17