Inactivation of PI(3)K p110δ breaks regulatory T-cell-mediated immune tolerance to cancer

Khaled Ali, Dalya R. Soond, Roberto Piñeiro, +11

Nature

Cancer ImmunosurveillanceT-regulatory CellImmunologyImmune RegulationCell Death +7

GWASdb: a database for human genetic variants identified by genome-wide association studies

Mulin Jun Li, Panwen Wang, Xiaorong Liu, +7

Nucleic Acids Research

Differential control of human Treg and effector T cells in tumor immunity by Fc-engineered anti–CTLA-4 antibody

Danbee Ha, Atsushi Tanaka, Tatsuya Kibayashi, +10

Proceedings of the National Academy of Sciences

Compensation between CSF1R+ macrophages and Foxp3+ Treg cells drives resistance to tumor immunotherapy

Dávid Győri, Ee Lyn Lim, Francis M. Grant, +6

JCI Insight

T-regulatory CellImmunologyImmune RegulationRegulatory T CellsImmunologic Mechanism +15

Phosphoinositide 3-kinase δ inhibition promotes antitumor responses but antagonizes checkpoint inhibitors

Ee Lyn Lim, Fiorella Cugliandolo, Dalya R. Soond, +3

JCI Insight

UNC93B1 variants underlie TLR7-dependent autoimmunity

Christine Wolf, Ee Lyn Lim, Mohammad Mokhtari, +30

Science Immunology

Overactive Tlr7Innate Immune SystemImmunologyImmune RegulationImmunologic Mechanism +24

Dual mechanisms by which miR-125b represses IRF4 to induce myeloid and B-cell leukemias

Alex Yick‐Lun So, Reeshelle Sookram, Aadel A. Chaudhuri, +10

Blood

Disrupted degradative sorting of TLR7 is associated with human lupus

Harshita Mishra, Claire Schlack-Leigers, Ee Lyn Lim, +10

Science Immunology

ImmunologyPathologyImmunotherapyInflammationImmunogenetics +17

Construction of a T cell receptor signaling range for spontaneous development of autoimmune disease

Atsushi Tanaka, Shinji Maeda, Takashi Nomura, +18

The Journal of Experimental Medicine

Lymphocyte DevelopmentAdaptive Immune SystemT-regulatory CellImmunologyImmune Regulation +17