Jacqueline M. Tarrant

Exploiting selective BCL-2 family inhibitors to dissect cell survival dependencies and define improved strategies for cancer therapy

Darren C. Phillips, Michael J. Mitten, Erwin R. Boghaert et al. · Science Translational Medicine · 2015 · 530 citations · Full text

Cancer Therapy, Chemoprevention Strategy, Bcl-2/bcl-xl/bcl-w Inhibitor Abt-263 +20

Effect of selective LRRK2 kinase inhibition on nonhuman primate lung

Reina N. Fuji, Michael Flagella, Miriam Baca et al. · Science Translational Medicine · 2015 · 363 citations

GS-0976 Reduces Hepatic Steatosis and Fibrosis Markers in Patients With Nonalcoholic Fatty Liver Disease

Rohit Loomba, Zeid Kayali, Mazen Noureddin et al. · Gastroenterology · 2018 · 329 citations · Full text

Obesity, Metabolic Syndrome, Metabolic Associated Steatohepatitis +12

Addressing Safety Liabilities of TfR Bispecific Antibodies That Cross the Blood-Brain Barrier

Jessica A. Couch, Yang Yu, Yin Zhang et al. · Science Translational Medicine · 2013 · 259 citations

Immunology, Immunotherapy, Cerebral Vascular Regulation +17

Acetyl-CoA Carboxylase Inhibitor GS-0976 for 12 Weeks Reduces Hepatic De Novo Lipogenesis and Steatosis in Patients With Nonalcoholic Steatohepatitis

Eric Lawitz, Angie Coste, Fred Poordad et al. · Clinical Gastroenterology and Hepatology · 2018 · 213 citations

Metabolic Syndrome, Metabolic Associated Steatohepatitis, Hepatology +12