Targeted disruption of the surfactant protein B gene disrupts surfactant homeostasis, causing respiratory failure in newborn mice.

J. C. Clark, Susan E. Wert, Cindy J. Bachurski, +4

Proceedings of the National Academy of Sciences

Acute Lung InjuryPulmonary SurfactantLung InflammationImmunologyPulmonary Alveolar Proteinosis +18

Production of immortalized distal respiratory epithelial cell lines from surfactant protein C/simian virus 40 large tumor antigen transgenic mice.

K. A. Wikenheiser, D. K. Vorbroker, Ward R. Rice, +4

Proceedings of the National Academy of Sciences

Viral ReplicationViral PathogenesisImmunologyPathologyPulmonary Alveolar Proteinosis +14

Human Mn-superoxide dismutase in pulmonary epithelial cells of transgenic mice confers protection from oxygen injury.

Jonathan R. Wispé, Barbara Warner, J. C. Clark, +6

Journal of Biological Chemistry

Acute Lung InjuryAsthmaLung InflammationLipid PeroxidationImmunology +15

Differential effects of epidermal growth factor and transforming growth factor-beta on synthesis of Mr = 35,000 surfactant-associated protein in fetal lung.

J. A. Whitsett, Timothy E. Weaver, M. A. Lieberman, +2

Journal of Biological Chemistry

Decreased lung compliance and air trapping in heterozygous SP-B-deficient mice.

J. C. Clark, Timothy E. Weaver, Harriet S. Iwamoto, +4

American Journal of Respiratory Cell and Molecular Biology

Acute Lung InjuryAsthmaInflammatory Lung DiseaseLung InflammationImmunology +17

cDNA, deduced polypeptide structure and chromosomal assignment of human pulmonary surfactant proteolipid, SPL(pVal).

Stephan W. Glasser, Thomas R. Korfhagen, Timothy E. Weaver, +4

Journal of Biological Chemistry

Proteinlipid InteractionHyaline Membrane DiseasePulmonary SurfactantPulmonary Alveolar ProteinosisMolecular Biology +14

Tumor necrosis factor-alpha inhibits expression of pulmonary surfactant protein.

Jonathan R. Wispé, J. C. Clark, Barbara Warner, +4

Journal of Clinical Investigation

Acute Lung InjuryPulmonary SurfactantInflammatory Lung DiseaseLung InflammationImmunology +16

Simian virus 40 large T antigen directed by transcriptional elements of the human surfactant protein C gene produces pulmonary adenocarcinomas in transgenic mice.

K. A. Wikenheiser, J. C. Clark, R. Ilona Linnoila, +2

PubMed

Viral ReplicationLarge T AntigenViral PathogenesisImmunologyPathology +19

Glucocorticoid enhances surfactant proteolipid Phe and pVal synthesis and RNA in fetal lung.

Jeffrey A. Whitsett, Timothy E. Weaver, J. C. Clark, +4

Journal of Biological Chemistry

Surfactant Proteolipid PheLung InflammationDistinct PrecursorsSurfactant ProteolipidsGlucocorticoid +15

Induction of surfactant protein in fetal lung. Effects of cAMP and dexamethasone on SAP-35 RNA and synthesis.

J. A. Whitsett, Thomas Pilot, J. C. Clark, +1

Journal of Biological Chemistry