Daryl S. Walter

Oral administration of a potent and selective non‐peptidic BACE‐1 inhibitor decreases β‐cleavage of amyloid precursor protein and amyloid‐β production <i>in vivo</i>

Ishrut Hussain, Julie A. Hawkins, David C. Harrison et al. · Journal of Neurochemistry · 2006 · 198 citations

Molecular Pharmacology, Alzheimer's Disease, Biochemistry +13

Discovery and structure–activity relationships of a series of pyroglutamic acid amide antagonists of the P2X7 receptor

Muna Abdi, Paul Beswick, Andy Billinton et al. · Bioorganic & Medicinal Chemistry Letters · 2010 · 70 citations · Full text

Molecular Pharmacology, Biochemistry, Medicine +10

Mechanism of action of species‐selective P2X₇receptor antagonists

Anton D. Michel, Sin‐Wei Ng, Shilina Roman et al. · British Journal of Pharmacology · 2009 · 64 citations · Full text

Second Generation of Hydroxyethylamine BACE-1 Inhibitors: Optimizing Potency and Oral Bioavailability

Nicolas Charrier, Brian Clarke, Leanne Cutler et al. · Journal of Medicinal Chemistry · 2008 · 64 citations · Full text

Pharmaceutical Science, Oral Bioavailability, Neurochemical Biomarkers +19

BACE-1 inhibitors part 3: Identification of hydroxy ethylamines (HEAs) with nanomolar potency in cells

Paul Beswick, Nicolas Charrier, Brian Clarke et al. · Bioorganic & Medicinal Chemistry Letters · 2008 · 57 citations · Full text

Medicinal Chemistry, Pharmaceutical Science, Biochemistry +10