De novo mutations in schizophrenia implicate synaptic networks

Menachem Fromer, Andrew Pocklington, David H. Kavanagh, +29

Nature

Synaptic PlasticityPsychotic DisorderPsychiatric GeneticsSchizophreniaConnectomics +5

CAG Repeat Not Polyglutamine Length Determines Timing of Huntington’s Disease Onset

Jong‐Min Lee, Kevin Correia, Jacob M. Loupe, +35

Cell

Neurodegenerative DiseasesHuntington ’Genetic DisorderGeneticsDegenerative Disease +6

Adenovirus proteins from both E1B reading frames are required for transformation of rodent cells by viral infection and DNA transfection

Douglas Barker, Arnold Berk

Virology

Viral ReplicationE1b Reading FramesNatural SciencesRodent CellsDna Transfection +7

Pumilio is essential for function but not for distribution of the Drosophila abdominal determinant Nanos.

Douglas Barker, Charlotte Wang, Jackie Moore, +2

Genes & Development

Characterization of bipolar disorder patient-specific induced pluripotent stem cells from a family reveals neurodevelopmental and mRNA expression abnormalities

Jon M. Madison, Fangjian Zhou, Aparna Nigam, +22

Molecular Psychiatry

Mrna Expression AbnormalitiesEmbryonic Stem CellInduced Pluripotent Stem CellDevelopmental BiologyMedicine +10

Dysregulation of miR-34a links neuronal development to genetic risk factors for bipolar disorder

Sabine Bavamian, Nikolaos Mellios, Jasmin Lalonde, +10

Molecular Psychiatry

PsychiatryMedicineGeneticsPsychiatric GeneticsNon-coding Rna +8

A Selective HDAC 1/2 Inhibitor Modulates Chromatin and Gene Expression in Brain and Alters Mouse Behavior in Two Mood-Related Tests

Frederick A. Schroeder, Michael C. Lewis, Daniel M. Fass, +14

PLoS ONE

Epigenetic ChangePsychopharmacologyEpigeneticsSocial SciencesHdac Inhibition +18

Crebinostat: A novel cognitive enhancer that inhibits histone deacetylase activity and modulates chromatin-mediated neuroplasticity

Daniel M. Fass, Surya A. Reis, Balaram Ghosh, +12

Neuropharmacology

Histone ModificationsChromatinNovel Cognitive EnhancerMolecular NeuroscienceChromatin Remodeling +10

Cis-acting regulation of brain-specific ANK3 gene expression by a genetic variant associated with bipolar disorder

Erroll H. Rueckert, Douglas Barker, Douglas M. Ruderfer, +11

Molecular Psychiatry

Genetic Risk Underlying Psychiatric and Cognitive Symptoms in Huntington’s Disease

Natalie Ellis, Amelia Tee, Branduff McAllister, +38

Biological Psychiatry