Giovanni Martino

CCNE1 amplification is synthetic lethal with PKMYT1 kinase inhibition

David Gallo, Jordan T.F. Young, Jimmy Fourtounis et al. · Nature · 2022 · 200 citations · Full text

Caspase-8-mediated Intracellular Acidification Precedes Mitochondrial Dysfunction in Somatostatin-induced Apoptosis

Danni Liu, Giovanni Martino, Muthusamy Thangaraju et al. · Journal of Biological Chemistry · 2000 · 118 citations · Full text

Mitochondrial Dysfunction, Apoptosis, Cell Death +16

The CIP2A–TOPBP1 axis safeguards chromosome stability and is a synthetic lethal target for BRCA-mutated cancer

Salomé Adam, Silvia Emma Rossi, Nathalie Moatti et al. · Nature Cancer · 2021 · 110 citations

Chromatin, Genome Instability, Medicine +11

Discovery of an Orally Bioavailable and Selective PKMYT1 Inhibitor, RP-6306

Janek Szychowski, Robert Papp, Evelyne Dietrich et al. · Journal of Medicinal Chemistry · 2022 · 63 citations · Full text

Discovery of P2X3 selective antagonists for the treatment of chronic pain

Louis‐David Cantin, Malken Bayrakdarian, Christophe Buon et al. · Bioorganic & Medicinal Chemistry Letters · 2012 · 30 citations · Full text

Pain Therapy, Health Sciences, Pain Medicine +12