Discovery of P2X3 selective antagonists for the treatment of chronic pain

A P2X purinoceptor expressed by a subset of sensory neurons

Chih‐Cheng Chen, Armen N. Akopian, Lucia G. Sivilotti et al. · Nature · 1995 · 1K citations

Neural Mechanism, Sensory Neuroscience, Neurophysiology +13

Urinary bladder hyporeflexia and reduced pain-related behaviour in P2X3-deficient mice

Debra A. Cockayne, Sara G. Hamilton, Quan‐Ming Zhu et al. · Nature · 2000 · 1K citations

Urological Research, Urology, Voiding Dysfunction +4

Coexpression of P2X2 and P2X3 receptor subunits can account for ATP-gated currents in sensory neurons

Carolyn J. Lewis, S. Neidhart, C. Holy et al. · Nature · 1995 · 997 citations

Molecular Physiology, Neurophysiology, P2x3 Receptor Subunits +11

A-317491, a novel potent and selective non-nucleotide antagonist of P2X ₃ and P2X _2/3 receptors, reduces chronic inflammatory and neuropathic pain in the rat

Michael F. Jarvis, Edward C. Burgard, Steve McGaraughty et al. · Proceedings of the National Academy of Sciences · 2002 · 458 citations · Full text

Warm-coding deficits and aberrant inflammatory pain in mice lacking P2X3 receptors

Veronika Souslova, Paolo Cesare, Yanning Ding et al. · Nature · 2000 · 449 citations

Inflammation, Anti-inflammatory, Molecular Physiology +14