John P. Vaillancourt

Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis

Donald W. Nicholson, Ambereen Ali, Nancy A. Thornberry et al. · Nature · 1995 · 4K citations

Protein Function, Biochemistry, Ice/ced-3 Protease +11

A Combinatorial Approach Defines Specificities of Members of the Caspase Family and Granzyme B

Nancy A. Thornberry, Thomas A. Rano, Erin P. Peterson et al. · Journal of Biological Chemistry · 1997 · 2.1K citations · Full text

Involvement of Caspases in Proteolytic Cleavage of Alzheimer’s Amyloid-β Precursor Protein and Amyloidogenic Aβ Peptide Formation

François G. Gervais, Daigen Xu, George S. Robertson et al. · Cell · 1999 · 785 citations · Full text

Neurodegenerative Diseases, Protein Function, Alzheimer's Disease +11

The three-dimensional structure of apopain/CPP32, a key mediator of apoptosis

J. Rotonda, Donald W. Nicholson, Kimberly M. Fazil et al. · Nature Structural Biology · 1996 · 432 citations

Protein Function, Signal Transduction, Biochemistry +12

Differential modulation of endotoxin responsiveness by human caspase-12 polymorphisms

Maya Saleh, John P. Vaillancourt, Rona K. Graham et al. · Nature · 2004 · 416 citations · Full text

Inflammation, Immunotoxicology, Immunology +5