Transition state analogs of 5′-methylthioadenosine nucleosidase disrupt quorum sensing

Jemy A. Gutierrez, Tamara Crowder, Agnes Rinaldo-Matthis, +3

Nature Chemical Biology

Transition State AnalogsNatural SciencesMolecular BiologyMolecular SwitchChemical Probe +1

A phosphoenzyme mimic, overlapping catalytic sites and reaction coordinate motion for human NAMPT

Emmanuel S. Burgos, Meng-Chiao Ho, Steven C. Almo, +1

Proceedings of the National Academy of Sciences

Four generations of transition-state analogues for human purine nucleoside phosphorylase

Meng-Chiao Ho, Wuxian Shi, Agnes Rinaldo-Matthis, +5

Proceedings of the National Academy of Sciences

Acyclic Immucillin Phosphonates: Second-Generation Inhibitors of Plasmodium falciparum Hypoxanthine- Guanine-Xanthine Phosphoribosyltransferase

Keith Z. Hazleton, Meng-Chiao Ho, María B. Cassera, +7

Chemistry & Biology

Medicinal ChemistryPharmaceutical ChemistryBiochemistryMedicineNatural Sciences +8

Transition state analogues in structures of ricin and saporin ribosome-inactivating proteins

Meng-Chiao Ho, Matthew B. Sturm, Steven C. Almo, +1

Proceedings of the National Academy of Sciences

Protein AssemblyMolecular BiologyChemical BiologyProtein SynthesisSusceptible Adenine +15

Characterizing DNA Methyltransferases With An Ultrasensitive Luciferase-Linked Continuous Assay

Ivan Hemeon, Jemy A. Gutierrez, Meng-Chiao Ho, +1

Analytical Chemistry

ChromatinMethyl GroupNucleic Acid BiomarkersAldehyde DehydrogenaseBiochemistry +11

Structural and Metabolic Specificity of Methylthiocoformycin for Malarial Adenosine Deaminases

Meng-Chiao Ho, María B. Cassera, Dennis C. Madrid, +5

Biochemistry

Crystal StructureBiosynthesisPlasmodium FalciparumCellular EnzymologyBiochemistry +11

Methylthioinosine Phosphorylase from<i>Pseudomonas aeruginosa</i>. Structure and Annotation of a Novel Enzyme in Quorum Sensing

Rong Guan, Meng-Chiao Ho, Steven C. Almo, +1

Biochemistry

Biomolecular Structure PredictionMolecular BiologyMta MetabolismMicrobial PhysiologyNovel Enzyme +14

Entropy-Driven Binding of Picomolar Transition State Analogue Inhibitors to Human 5′-Methylthioadenosine Phosphorylase

Rong Guan, Meng-Chiao Ho, Michael Brenowitz, +4

Biochemistry

Molecular BiologyChemical BiologyPharmaceutical ChemistryHomotrimeric MtapMolecular Pharmacology +17

Inhibition and Structure of Toxoplasma gondii Purine Nucleoside Phosphorylase

Teraya Donaldson, María B. Cassera, Meng-Chiao Ho, +7

Eukaryotic Cell

Cellular EnzymologyBiochemistryTgpnp InhibitionPurine SalvageNatural Sciences +11