Ann Qin

Discovery of (<i>S</i>)-1-(1-(4-Chloro-3-fluorophenyl)-2-hydroxyethyl)-4-(2-((1-methyl-1<i>H</i>-pyrazol-5-yl)amino)pyrimidin-4-yl)pyridin-2(1<i>H</i>)-one (GDC-0994), an Extracellular Signal-Regulated Kinase 1/2 (ERK1/2) Inhibitor in Early Clinical Development

James F. Blake, Michael Burkard, Jocelyn Chan et al. · Journal of Medicinal Chemistry · 2016 · 158 citations · Full text

Medicine, Oncology, Pharmacology +17

Supplementation of Nicotinic Acid with NAMPT Inhibitors Results in Loss of In Vivo Efficacy in NAPRT1-Deficient Tumor Models

Thomas O’Brien, Jason Oeh, Yang Xiao et al. · Neoplasia · 2013 · 58 citations · Full text

Medicine, Oncology, Pharmacology +16

Evaluation of Homogenization Techniques for the Preparation of Mouse Tissue Samples to Support Drug Discovery

Xiaorong Liang, Savita Ubhayakar, Bianca M. Liederer et al. · Bioanalysis · 2011 · 47 citations

Medicine, Biochemistry, Pharmacology +13

Highly selective c-Jun N-terminal kinase (JNK) 2 and 3 inhibitors with in vitro CNS-like pharmacokinetic properties prevent neurodegeneration

Gary D. Probst, Simeon Bowers, Jennifer M. Sealy et al. · Bioorganic & Medicinal Chemistry Letters · 2010 · 44 citations · Full text

Life Sciences, Neuroscience, Pharmacology +14

A reversed sulfonamide series of selective RORc inverse agonists

Monique B. van Niel, Benjamin P. Fauber, Matthew W. Cartwright et al. · Bioorganic & Medicinal Chemistry Letters · 2014 · 36 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +6