Twana Saleh

Discovery of (<i>R</i>)-8-(1-(3,5-Difluorophenylamino)ethyl)-<i>N</i>,<i>N</i>-dimethyl-2-morpholino-4-oxo-4<i>H</i>-chromene-6-carboxamide (AZD8186): A Potent and Selective Inhibitor of PI3Kβ and PI3Kδ for the Treatment of PTEN-Deficient Cancers

Bernard Barlaam, Sabina Cosulich, Sébastien L. Degorce et al. · Journal of Medicinal Chemistry · 2014 · 87 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +13

Discovery of 1-(4-(5-(5-amino-6-(5-tert-butyl-1,3,4-oxadiazol-2-yl)pyrazin-2-yl)-1-ethyl-1,2,4-triazol-3-yl)piperidin-1-yl)-3-hydroxypropan-1-one (AZD8835): A potent and selective inhibitor of PI3Kα and PI3Kδ for the treatment of cancers

Bernard Barlaam, Sabina Cosulich, Bénédicte Delouvrié et al. · Bioorganic & Medicinal Chemistry Letters · 2015 · 35 citations

Medicine, Medicinal Chemistry, Pharmacology +8

Controlling Mode Selectivity in Palladium-Catalyzed Bisdiene Carbocyclizations:  Optimizing for Cyclization-Trapping over Cycloisomerization

James M. Takacs, Scott D. Schroeder, Jianxin Han et al. · Organic Letters · 2003 · 25 citations

Natural Sciences, Chemical Engineering, Chemistry +16

Discovery of 9-(1-anilinoethyl)-2-morpholino-4-oxo-pyrido[1,2-a]pyrimidine-7-carboxamides as PI3Kβ/δ inhibitors for the treatment of PTEN-deficient tumours

Bernard Barlaam, Sabina Cosulich, Sébastien L. Degorce et al. · Bioorganic & Medicinal Chemistry Letters · 2014 · 19 citations · Full text

Medicine, Oncology, Pharmacology +10

Preparation of (±)-1-Allyl-4-deoxy Mannose Derivatives

Twana Saleh, Gérard Rousseau · Synlett · 1999 · 11 citations

Pharmacy, Chemistry, Pharmacology +8