Controlling Mode Selectivity in Palladium-Catalyzed Bisdiene Carbocyclizations: Optimizing for Cyclization-Trapping over Cycloisomerization

Abstract

[reaction: see text] Screening combinations of five catalyst precursors with 13 phosphorus ligands identified cyclization catalysts that favor carbocyclization-trapping with N-hydroxyphthalimide over a competing cycloisomerization mode.