Zhiren Xia

A peripherally acting, selective T-type calcium channel blocker, ABT-639, effectively reduces nociceptive and neuropathic pain in rats

Michael F. Jarvis, Victoria E. Scott, Steve McGaraughty et al. · Biochemical Pharmacology · 2014 · 72 citations

Molecular Pharmacology, Pain Therapy, Health Sciences +11

1,4-Dihydroindeno[1,2-<i>c</i>]pyrazoles with Acetylenic Side Chains as Novel and Potent Multitargeted Receptor Tyrosine Kinase Inhibitors with Low Affinity for the hERG Ion Channel

Jürgen Dinges, Daniel H. Albert, Lee D. Arnold et al. · Journal of Medicinal Chemistry · 2007 · 31 citations · Full text

Chemoprevention Strategy, Pharmacotherapy, Pharmaceutical Chemistry +21

Efficient Pd-catalyzed synthesis of 2-arylaminopyrimidines via microwave irradiation

Henry Q. Zhang, Zhiren Xia, Anil Vasudevan et al. · Tetrahedron Letters · 2006 · 24 citations

Engineering, Organic Chemistry, Microwave Irradiation +5

Hit-to-lead optimization of 1,4-dihydroindeno[1,2-c]pyrazoles as a novel class of KDR kinase inhibitors

Jürgen Dinges, Irini Akritopoulou‐Zanze, Lee D. Arnold et al. · Bioorganic & Medicinal Chemistry Letters · 2006 · 22 citations · Full text

Combinatorial Chemistry, Medicinal Chemistry, Drug Target +10

Optimization of ADME Properties for Sulfonamides Leading to the Discovery of a T-Type Calcium Channel Blocker, ABT-639

Qingwei Zhang, Zhiren Xia, Shailen K. Joshi et al. · ACS Medicinal Chemistry Letters · 2015 · 22 citations · Full text

Oral Bioavailability, Pain Medicine, Experimental Pain Models +18