Jay Harper

Matrix metalloproteinase-2 is required for the switch to the angiogenic phenotype in a tumor model

Jianmin Fang, Yuen Shing, Dmitri Wiederschain et al. · Proceedings of the National Academy of Sciences · 2000 · 392 citations

Medicine, Oncology, Pathology +15

Antibody–Drug Conjugates Bearing Pyrrolobenzodiazepine or Tubulysin Payloads Are Immunomodulatory and Synergize with Multiple Immunotherapies

Jonathan Rios‐Doria, Jay Harper, Raymond Rothstein et al. · Cancer Research · 2017 · 134 citations

Medicine, Immunology, Pharmacology +17

Pre-clinical pharmacology and mechanism of action of SG3199, the pyrrolobenzodiazepine (PBD) dimer warhead component of antibody-drug conjugate (ADC) payload tesirine

John A. Hartley, Michael Flynn, John P. Bingham et al. · Scientific Reports · 2018 · 129 citations · Full text

Medicine, Oncology, Pharmacology +14

Stabilization of cysteine-linked antibody drug conjugates with N-aryl maleimides

R. James Christie, Ryan Fleming, Binyam Bezabeh et al. · Journal of Controlled Release · 2015 · 125 citations

Pharmacy, Medicinal Chemistry, Pharmaceutics +14

VEGF-A Induces Angiogenesis by Perturbing the Cathepsin-Cysteine Protease Inhibitor Balance in Venules, Causing Basement Membrane Degradation and Mother Vessel Formation

Sung-Hee Chang, Keizo Kanasaki, Vasilena Gocheva et al. · Cancer Research · 2009 · 120 citations · Full text

Life Sciences, Cell Biology, Molecular Biology +15