Ryan Fleming

A Biparatopic HER2-Targeting Antibody-Drug Conjugate Induces Tumor Regression in Primary Models Refractory to or Ineligible for HER2-Targeted Therapy

John Y. Li, Samuel R. Perry, Vanessa Muniz‐Medina et al. · Cancer Cell · 2016 · 390 citations · Full text

Medicine, Oncology, Pharmacology +14

A multifunctional bispecific antibody protects against <i>Pseudomonas aeruginosa</i>

Antonio DiGiandomenico, Ashley Keller, Cuihua Gao et al. · Science Translational Medicine · 2014 · 280 citations

Pharmacy, Infectious Diseases, Microbiology +14

A Human Antibody–Drug Conjugate Targeting EphA2 Inhibits Tumor Growth<i>In vivo</i>

Dowdy Jackson, John Gooya, Shenlan Mao et al. · Cancer Research · 2008 · 151 citations · Full text

Pharmacy, Oncology, Pharmacology +15

Antibody–Drug Conjugates Bearing Pyrrolobenzodiazepine or Tubulysin Payloads Are Immunomodulatory and Synergize with Multiple Immunotherapies

Jonathan Rios‐Doria, Jay Harper, Raymond Rothstein et al. · Cancer Research · 2017 · 134 citations

Medicine, Immunology, Pharmacology +17

Stabilization of cysteine-linked antibody drug conjugates with N-aryl maleimides

R. James Christie, Ryan Fleming, Binyam Bezabeh et al. · Journal of Controlled Release · 2015 · 125 citations

Pharmacy, Medicinal Chemistry, Pharmaceutics +14