Syeed Hussain

Optimization of a Novel Binding Motif to (<i>E</i>)-3-(3,5-Difluoro-4-((1<i>R</i>,3<i>R</i>)-2-(2-fluoro-2-methylpropyl)-3-methyl-2,3,4,9-tetrahydro-1<i>H</i>-pyrido[3,4-<i>b</i>]indol-1-yl)phenyl)acrylic Acid (AZD9496), a Potent and Orally Bioavailable Selective Estrogen Receptor Downregulator and Antagonist

Chris De Savi, Robert H. Bradbury, Alfred A. Rabow et al. · Journal of Medicinal Chemistry · 2015 · 159 citations · Full text

Pharmaceutical Science, Pharmacotherapy, Positive Breast Cancer +18

Structural Insights into Substrate Specificity and the <i>anti</i> β-Elimination Mechanism of Pectate Lyase

Arefeh Seyedarabi, Teng Teng To, Salyha Ali et al. · Biochemistry · 2009 · 56 citations

Pectate Lyase, Glycobiology, Molecular Biology +17

Generation of Nucleophilic Character in the Cys25/His159 Ion Pair of Papain Involves Trp177 but Not Asp158

Sheraz Gul, Syeed Hussain, Mark Thomas et al. · Biochemistry · 2008 · 34 citations

Structure of internalin C from<i>Listeria monocytogenes</i>

Amy Ooi, Syeed Hussain, Arefeh Seyedarabi et al. · Acta Crystallographica Section D Biological Crystallography · 2006 · 23 citations · Full text

Discovery of novel Jak2–Stat pathway inhibitors with extended residence time on target

Huiping Guan, Michelle L. Lamb, Bo Peng et al. · Bioorganic & Medicinal Chemistry Letters · 2013 · 22 citations · Full text

Molecular Pharmacology, Signal Transduction, Biochemistry +9