Vitamin E down-modulates iNOS and NADPH oxidase in c-Myc/TGF-α transgenic mouse model of liver cancer

Diego F. Calvisi, Sara Ladu, Koji Hironaka, +2

Journal of Hepatology

Cancer MetabolismRedox SignalingHepatologyNadph OxidaseMedicine +10

Quantitative Analysis of Liver Fibrosis and Stellate Cell Changes in Patients With Chronic Hepatitis C After Interferon Therapy

I SAKAIDA, Atsuko Nagatomi, Koji Hironaka, +2

The American Journal of Gastroenterology

Enhanced Interstitial Collagenase (Matrix Metalloproteinase-13) Production of Kupffer Cell by Gadolinium Chloride Prevents Pig Serum-Induced Rat Liver Fibrosis

Koji Hironaka, Isao Sakaida, Yasuhiro Matsumura, +3

Biochemical and Biophysical Research Communications

Tissue EngineeringInflammationFibrosisHepatologyLiver Physiology +12

Fibrosis Accelerates the Development of Enzyme–Altered Lesions in the Rat Liver

Isao Sakaida, Koji Hironaka, Koichi Uchida, +3

Hepatology

Gadolinium chloride reverses dimethylnitrosamine (DMN)-induced rat liver fibrosis with increased matrix metalloproteinases (MMPs) of Kupffer cells

Isao Sakaida, Koji Hironaka, Shuji Terai, +1

Life Sciences

InflammationFibrosisHepatologyLiver PhysiologyExtracellular Matrix +13

Herbal medicine Sho-saiko-to (TJ-9) increases expression matrix metalloproteinases (MMPs) with reduced expression of tissue inhibitor of metalloproteinases (TIMPs) in rat stellate cell

Isao Sakaida, Koji Hironaka, Teruaki Kimura, +3

Life Sciences

InflammationCytokineAllergyAutoimmune DiseaseMedicine +8

Dysregulation of DNA Repair Pathways in a Transforming Growth Factor α/c-myc Transgenic Mouse Model of Accelerated Hepatocarcinogenesis

Koji Hironaka, Valentina M. Factor, Diego F. Calvisi, +2

Laboratory Investigation

Tumor BiologyHepatologyHepatocellular CarcinomaMedicineLiver Physiology +9

Prolyl 4-hydroxylase inhibitor (HOE 077) prevents TIMP-1 gene expression in rat liver fibrosis

Isao Sakaida, Koichi Uchida, Koji Hironaka, +1

Journal of Gastroenterology

InflammationHoe 077FibrosisHepatologyLiver Physiology +10

Ubiquitin and hepatocellular carcinoma

Hitoshi Shirahashi, Isao Sakaida, Shuji Terai, +3

Liver International

Correlation Between Stellate Cell Activation and Serum Fibrosis Markers in Choline-Deficient l-Amino Acid-Defined Diet-Induced Rat Liver Fibrosis

Koji Hironaka, Isao Sakaida, Koichi Uchida, +1

Digestive Diseases and Sciences