Makiko Mizumoto

T140 analogs as CXCR4 antagonists identified as anti‐metastatic agents in the treatment of breast cancer

Hirokazu Tamamura, Akira Hori, Naoyuki Kanzaki et al. · FEBS Letters · 2003 · 281 citations · Full text

Inhibitory Activity, T140 Analogs, Breast Oncology +14

Identification of a CXCR4 antagonist, a T140 analog, as an anti‐rheumatoid arthritis agent

Hirokazu Tamamura, Miho Fujisawa, Kenichi Hiramatsu et al. · FEBS Letters · 2004 · 137 citations · Full text

Unequivocal Synthesis of (<i>Z</i>)-Alkene and (<i>E</i>)-Fluoroalkene Dipeptide Isosteres To Probe Structural Requirements of the Peptide Transporter PEPT1

Ayumu Niida, Kenji Tomita, Makiko Mizumoto et al. · Organic Letters · 2006 · 110 citations

Peptide Transporter Pept1, Molecular Biology, Organic Chemistry +17

Enhancement of the T140-based pharmacophores leads to the development of more potent and bio-stable CXCR4 antagonistsElectronic supplementary information (ESI) available: Fig. S1: behaviors of TF14013, TF14016 and TF14013-Me in mouse serum; Fig. S2: behaviors of TF14002 (a), TF14005 (b), TF14006 (c), TF14013 (d), TF14016 (e) and TF14013 analogs (f) in rat liver homogenate; Table S1: characterization data of novel synthetic peptides; and HPLC charts for synthetic compounds of 4F-benzoyl-TE14011 (TF14013), 4F-benzoyl-TN14003 (TF14016), nicotinoyl-TE14011 (TF14031) and 4F-benzoyl-TE14011-Me (TF14013-Me), and for a degraded sample of 4F-benzoyl-TE14011 (TF14013) in rat liver homogenate and its co-injection with an authentic compound des-[Arg14-NH2]-4F-benzoyl-TE14011. See http://www.rsc.org/suppdata/ob/b3/b306613b/

Hirokazu Tamamura, Kenichi Hiramatsu, Makiko Mizumoto et al. · Organic & Biomolecular Chemistry · 2003 · 95 citations

Synthesis of (<i>Z</i>)-Alkene and (<i>E</i>)-Fluoroalkene-Containing Diketopiperazine Mimetics Utilizing Organocopper-Mediated Reduction−Alkylation and Diastereoselectivity Examination Using DFT Calculations

Ayumu Niida, Makiko Mizumoto, Tetsuo Narumi et al. · The Journal of Organic Chemistry · 2006 · 31 citations

Unexpected 3,6-Cis Isomers, Engineering, Alkene Metathesis +10