Molecular Signature of CD8+ T Cell Exhaustion during Chronic Viral Infection

E. John Wherry, Sang‐Jun Ha, Susan M. Kaech, +7

Immunity

Viral PersistenceHuman RetrovirusImmunologyAntiviral ResponseVirology +7

Functional and genomic profiling of effector CD8 T cell subsets with distinct memory fates

Surojit Sarkar, Vandana Kalia, W. Nicholas Haining, +3

The Journal of Experimental Medicine

Adaptive Immune SystemEffector SubsetsImmunologyImmune RegulationImmunologic Mechanism +17

Prolonged Interleukin-2Rα Expression on Virus-Specific CD8+ T Cells Favors Terminal-Effector Differentiation In Vivo

Vandana Kalia, Surojit Sarkar, Shruti Subramaniam, +3

Immunity

Adaptive Immune SystemImmunologyImmunologic MechanismT Cell ImmunityCd4 T Cell Responses +7

Antigen-specific CD4 T-cell help rescues exhausted CD8 T cells during chronic viral infection

Rachael D. Aubert, Alice O. Kamphorst, Surojit Sarkar, +7

Proceedings of the National Academy of Sciences

T-regulatory CellImmunologyImmune RegulationCd4 T Cell ResponsesImmunotherapy +15

Requirement of B Cells for Generating CD4+ T Cell Memory

Jason K. Whitmire, Mary S. Asano, Susan M. Kaech, +4

The Journal of Immunology

Autoimmune DiseaseAdaptive Immune SystemT Cell MemoryHumoral ResponseImmunology +11

Strength of Stimulus and Clonal Competition Impact the Rate of Memory CD8 T Cell Differentiation

Surojit Sarkar, Volker Teichgräber, Vandana Kalia, +5

The Journal of Immunology

Quiescence of Memory CD8+ T Cells Is Mediated by Regulatory T Cells through Inhibitory Receptor CTLA-4

Vandana Kalia, Laura A. Penny, Yevgeniy Yuzefpolskiy, +2

Immunity

Signal TransductionAutoimmune DiseaseMedicineT-regulatory CellImmunology +7

Interleukin-21 Is a Critical Cytokine for the Generation of Virus-Specific Long-Lived Plasma Cells

Mohammed Ata Ur Rasheed, Donald R. Latner, Rachael D. Aubert, +11

Journal of Virology

Humoral ResponseImmunologyImmunologic MechanismImmunotherapyInflammation +15

MicroRNA-17∼92 regulates effector and memory CD8 T-cell fates by modulating proliferation in response to infections

Arif A. Khan, Laura A. Penny, Yevgeniy Yuzefpolskiy, +2

Blood

Demethylation of the PD-1 Promoter Is Imprinted during the Effector Phase of CD8 T Cell Exhaustion

Eunseon Ahn, Ben Youngblood, Junghwa Lee, +3

Journal of Virology