Chris J. Novotny

Overcoming mTOR resistance mutations with a new-generation mTOR inhibitor

Vanessa Rodrik-Outmezguine, Masanori Okaniwa, Zhan Yao et al. · Nature · 2016 · 469 citations

Medicine, Mtor Resistance Mutations, Molecular Biology +4

A Kinase Inhibitor Targeted to mTORC1 Drives Regression in Glioblastoma

Qi-Wen Fan, Ozlem Aksoy, Robyn A. Wong et al. · Cancer Cell · 2017 · 176 citations

Neuro-oncology, Radiation Oncology, Kinase Inhibitor +8

Procaspase-3 Activation as an Anti-Cancer Strategy: Structure−Activity Relationship of Procaspase-Activating Compound 1 (PAC-1) and Its Cellular Co-Localization with Caspase-3

Quinn P. Peterson, Danny Hsu, David R. Goode et al. · Journal of Medicinal Chemistry · 2009 · 154 citations · Full text

Anti-cancer Strategy, Apoptosis, Immunology +16

Discovery and Canine Preclinical Assessment of a Nontoxic Procaspase-3–Activating Compound

Quinn P. Peterson, Danny Hsu, Chris J. Novotny et al. · Cancer Research · 2010 · 65 citations · Full text

Pharmacokinetics and derivation of an anticancer dosing regimen for PAC-1, a preferential small molecule activator of procaspase-3, in healthy dogs

Pamela Lucas, Joanna Schmit, Quinn P. Peterson et al. · Investigational New Drugs · 2010 · 47 citations · Full text

Medicine, Pharmacology, Healthy Dogs +5