Martin Grundy

DNA repair contributes to the drug-resistant phenotype of primary acute myeloid leukaemia cells with FLT3 internal tandem duplications and is reversed by the FLT3 inhibitor PKC412

Claire Seedhouse, Hannah Hunter, Bethan Lloyd‐Lewis et al. · Leukemia · 2006 · 81 citations

Hematological Malignancy, Genome Instability, Drug-resistant Phenotype +10

Analysis of factors that affect in vitro chemosensitivity of leukaemic stem and progenitor cells to gemtuzumab ozogamicin (Mylotarg) in acute myeloid leukaemia

Mays Jawad, Claire Seedhouse, Ullas Mony et al. · Leukemia · 2009 · 45 citations · Full text

Progenitor Cells, Hematological Malignancy, Leukaemic Stem +11

The FLT3 Internal Tandem Duplication Mutation Is a Secondary Target of the Aurora B Kinase Inhibitor AZD1152-HQPA in Acute Myelogenous Leukemia Cells

Martin Grundy, Claire Seedhouse, Shilli Shang et al. · Molecular Cancer Therapeutics · 2010 · 41 citations · Full text

Mixed-phenotype Acute Leukemia, Tumor Biology, Myeloid Neoplasia +17

The expression of P‐glycoprotein in AML cells with <i>FLT3</i> internal tandem duplications is associated with reduced apoptosis in response to FLT3 inhibitors

Hannah Hunter, Monica Pallis, Claire Seedhouse et al. · British Journal of Haematology · 2004 · 40 citations

Apoptosis, Pgp Positivity, Cell Death +18

Sequential Influences of Leukemia-Specific and Genetic Factors on P-Glycoprotein Expression in Blasts from 817 Patients Entered into the National Cancer Research Network Acute Myeloid Leukemia 14 and 15 Trials

Claire Seedhouse, Martin Grundy, P. Bruce White et al. · Clinical Cancer Research · 2007 · 40 citations