Concepedia

DNA repair contributes to the drug-resistant phenotype of primary acute myeloid leukaemia cells with FLT3 internal tandem duplications and is reversed by the FLT3 inhibitor PKC412

Claire Seedhouse, Hannah Hunter, Bethan Lloyd‐Lewis, A. Massip, Monica Pallis, G I Carter, Martin Grundy, Shili Shang, Nigel H. Russell

Leukemia · 2006 · 81 citations · 29 references

DOI

Concepts

References

29

The Importance of Diagnostic Cytogenetics on Outcome in AML: Analysis of 1,612 Patients Entered Into the MRC AML 10 Trial

David Grimwade, Helen M. Walker, Fiona Oliver et al. · Blood · 1998 · 2.6K citations · Full text

Evidence for a lack of DNA double-strand break repair in human cells exposed to very low x-ray doses

Kai Rothkamm, Markus Löbrich · Proceedings of the National Academy of Sciences · 2003 · 1.6K citations · Full text

The presence of a FLT3 internal tandem duplication in patients with acute myeloid leukemia (AML) adds important prognostic information to cytogenetic risk group and response to the first cycle of chemotherapy: analysis of 854 patients from the United Kingdom Medical Research Council AML 10 and 12 trials

Panagiotis Kottaridis, Rosemary E. Gale, Marion E. Frew et al. · Blood · 2001 · 1.5K citations · Full text

Internal tandem duplication of the flt3 gene found in acute myeloid leukemia.

Mitsushige Nakao, S Yokota, Toshiki Iwai et al. · PubMed · 1996 · 1.2K citations

Activating mutation of D835 within the activation loop of FLT3 in human hematologic malignancies

Yukiya Yamamoto · Blood · 2001 · 1.1K citations