James A. Johnston

Mutations of Jak-3 gene in patients with autosomal severe combined immune deficiency (SCID)

Paolo Macchi, Anna Villa, Silvia Giliani et al. · Nature · 1995 · 882 citations

Primary Immunodeficiency, Immunogenetics, Immune Deficiency +10

Interaction of IL-2Rβ and γ _c Chains with Jak1 and Jak3: Implications for XSCID and XCID

Sarah M. Russell, James A. Johnston, Masayuki Noguchi et al. · Science · 1994 · 653 citations

Tumor immunogenicity determines the effect of B7 costimulation on T cell-mediated tumor immunity.

Lieping Chen, Patrick O. McGowan, S Ashe et al. · The Journal of Experimental Medicine · 1994 · 470 citations · Full text

Adaptive Immune System, Immunology, Murine B7 +16

Interleukin 12 induces tyrosine phosphorylation and activation of STAT4 in human lymphocytes.

Chris M. Bacon, Emanuel F. Petricoin, John R. Ortaldo et al. · Proceedings of the National Academy of Sciences · 1995 · 445 citations · Full text

Il-12-induced Gene Expression, T-regulatory Cell, Immunology +18

Molecular cloning of L-JAK, a Janus family protein-tyrosine kinase expressed in natural killer cells and activated leukocytes.

Masaru Kawamura, Daniel W. McVicar, James A. Johnston et al. · Proceedings of the National Academy of Sciences · 1994 · 303 citations · Full text

Innate Immune System, Immunology, Immune Regulation +20