Duncan C. Miller

FragLites—Minimal, Halogenated Fragments Displaying Pharmacophore Doublets. An Efficient Approach to Druggability Assessment and Hit Generation

D.J. Wood, J. Daniel Lopez‐Fernandez, Leanne E. Knight et al. · Journal of Medicinal Chemistry · 2019 · 101 citations · Full text

Pharmaceutical Science, Drug Target, Hit Identification +22

Structure-Based Design of Potent and Orally Active Isoindolinone Inhibitors of MDM2-p53 Protein–Protein Interaction

Gianni Chessari, Ian R. Hardcastle, Jong Sook Ahn et al. · Journal of Medicinal Chemistry · 2021 · 52 citations

Investigation of the effect of molecular properties on the binding kinetics of a ligand to its biological target

Duncan C. Miller, Graham Lunn, Peter Jones et al. · MedChemComm · 2012 · 51 citations

Chemical Biology, Molecular Properties, Drug Target +15

Discovery of Potent & Selective Inhibitors of Activated Thrombin-Activatable Fibrinolysis Inhibitor for the Treatment of Thrombosis

Mark E. Bunnage, Julian Blagg, John Steele et al. · Journal of Medicinal Chemistry · 2007 · 42 citations · Full text

Pharmaceutical Science, Selective Inhibitors, Pharmacotherapy +24

The discovery and optimization of benzimidazoles as selective NaV1.8 blockers for the treatment of pain

Alan D. Brown, Sharan K. Bagal, Paul G. Blackwell et al. · Bioorganic & Medicinal Chemistry · 2018 · 26 citations · Full text

Medicinal Chemistry, Pharmaceutical Science, Health Sciences +12