Xiaode Lu

Redesigning an FKBP–ligand interface to generate chemical dimerizers with novel specificity

Tim Clackson, Yang Wu, Leonard W. Rozamus et al. · Proceedings of the National Academy of Sciences · 1998 · 557 citations · Full text

Fkbp–ligand Interface, Protein Assembly, Molecular Biology +19

Molecular basis for interaction of the protein tyrosine kinase ZAP-70 with the T-cell receptor

Marcos Hatada, Xiaode Lu, Ellen R. Laird et al. · Nature · 1995 · 347 citations

Signal Transduction, G Protein-coupled Receptor, Receptor Tyrosine Kinase +9

Structure of HIV-1 reverse transcriptase/DNA complex at 7 Å resolution showing active site locations

Alfredo Jacobo‐Molina, Raymond G. Nanni, Roger Williams et al. · Nature · 1992 · 187 citations

Virus Structure, Viral Replication, Viral Polymerase Structure +12

Structure-based design of an osteoclast-selective, nonpeptide Src homology 2 inhibitor with <i>in vivo</i> antiresorptive activity

William C. Shakespeare, Michael G. Yang, Regine S. Bohacek et al. · Proceedings of the National Academy of Sciences · 2000 · 133 citations · Full text

Medicinal Chemistry, Sclerostin, Biochemistry +15

Structure-based design and synthesis of a novel class of Src SH2 inhibitors

John L. Buchanan, Regine S. Bohacek, George P. Luke et al. · Bioorganic & Medicinal Chemistry Letters · 1999 · 30 citations · Full text

Combinatorial Chemistry, Medicinal Chemistry, Biochemistry +11