Partitioning heritability by functional annotation using genome-wide association summary statistics

Hilary K. Finucane, Brendan Bulik‐Sullivan, Alexander Gusev, +18

Nature Genetics

Genome-wide Association StudyGenetic AnalysisGenotype-phenotype AssociationGeneticsLinkage Analysis +10

MAGeCK enables robust identification of essential genes from genome-scale CRISPR/Cas9 knockout screens

Wei Li, Han Xu, Tengfei Xiao, +7

Genome biology

EngineeringGeneticsMolecular BiologyGenomicsEssential Genes +17

Computational correction of copy number effect improves specificity of CRISPR–Cas9 essentiality screens in cancer cells

Robin M. Meyers, Jordan Bryan, James M. McFarland, +28

Nature Genetics

GeneticsGenetic EngineeringCrispr–cas9 Essentiality ScreensGene EditingGenome Editing +5

EZH2 Oncogenic Activity in Castration-Resistant Prostate Cancer Cells Is Polycomb-Independent

Kexin Xu, Zhenhua J. Wu, Anna C. Groner, +19

Science

Histone ModificationsEpigenetic ChangeCancer BiologyEpigeneticsTumor Biology +20

Sequence determinants of improved CRISPR sgRNA design

Han Xu, Tengfei Xiao, Chen-Hao Chen, +9

Genome Research

BioinformaticsCrispr/cas9 Knockout ExperimentsOff-target EffectCrispr/cas9 SystemNatural Sciences +11

Chromatin marks identify critical cell types for fine mapping complex trait variants

Gosia Trynka, Cynthia Sandor, Buhm Han, +4

Nature Genetics

ChromatinChromatin RemodelingChromatin MarksGeneticsEpigenomics +8

Partitioning Heritability of Regulatory and Cell-Type-Specific Variants across 11 Common Diseases

Alexander Gusev, Sang Lee, Gosia Trynka, +338

The American Journal of Human Genetics

Genome-wide Association StudyAllelic VariantPhenotypic VariationGenotype-phenotype AssociationMedicine +10

Genomic Copy Number Dictates a Gene-Independent Cell Response to CRISPR/Cas9 Targeting

Andrew J. Aguirre, Robin M. Meyers, Barbara A. Weir, +27

Cancer Discovery

Quality control, modeling, and visualization of CRISPR screens with MAGeCK-VISPR

Wei Li, Johannes Köster, Han Xu, +5

Genome biology

Genome-scale deletion screening of human long non-coding RNAs using a paired-guide RNA CRISPR–Cas9 library

Shiyou Zhu, Wei Li, Jingze Liu, +11

Nature Biotechnology

GeneticsMolecular BiologyGene EditingGenome EditingGenomics +4