Jeffrey Chen

A selective small molecule inhibitor of c-Met kinase inhibits c-Met-dependent phenotypes in vitro and exhibits cytoreductive antitumor activity in vivo.

James G. Christensen, Randall Schreck, Jon Burrows et al. · PubMed · 2003 · 497 citations

Medicine, Oncology, Pharmacology +15

Proteolysis Involving Matrix Metalloproteinase 13 (Collagenase-3) Is Required for Chondrocyte Differentiation That Is Associated with Matrix Mineralization

Chenyan Wu, Elena V. Tchetina, Fackson Mwale et al. · Journal of Bone and Mineral Research · 2002 · 122 citations · Full text

Life Sciences, Cell Biology, Developmental Biology +14

Discovery of 6-(2,4-Difluorophenoxy)-2-[3-hydroxy-1-(2-hydroxyethyl)propylamino]-8-methyl-8<i>H</i>-pyrido[2,3-<i>d</i>]pyrimidin-7-one (Pamapimod) and 6-(2,4-Difluorophenoxy)-8-methyl-2-(tetrahydro-2<i>H</i>-pyran-4-ylamino)pyrido[2,3-<i>d</i>]pyrimidin-7(8<i>H</i>)-one (R1487) as Orally Bioavailable and Highly Selective Inhibitors of p38α Mitogen-Activated Protein Kinase

David Goldstein, Michael Soth, Tobias Gabriel et al. · Journal of Medicinal Chemistry · 2011 · 74 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +11

Nuclear insulin receptor substrate-1 activates promoters of cell cycle progression genes

Anguo Wu, Jeffrey Chen, Renato Baserga · Oncogene · 2007 · 71 citations

Life Sciences, Cell Biology, Molecular Biology +14

Transformation by the simian virus 40 T antigen is regulated by IGF-I receptor and IRS-1 signaling

Tiziana DeAngelis, Jeffrey Chen, Anguo Wu et al. · Oncogene · 2005 · 58 citations

Life Sciences, Immunology, Molecular Biology +9