VISTA is an inhibitory immune checkpoint that is increased after ipilimumab therapy in patients with prostate cancer

Jianjun Gao, John F. Ward, Curtis A. Pettaway, +16

Nature Medicine

Ipilimumab TherapyMedicineImmunologyImmune Checkpoint InhibitorCancer Treatment +5

Clonal expansion of CD8 T cells in the systemic circulation precedes development of ipilimumab-induced toxicities

Sumit K. Subudhi, Ana M. Aparicio, Jianjun Gao, +14

Proceedings of the National Academy of Sciences

Characterization of two grouper Epinephelus akaara cell lines: Application to studies of Singapore grouper iridovirus (SGIV) propagation and virus–host interaction

Xiaohong Huang, Youhua Huang, Jingjing Sun, +2

Aquaculture

Virus–host InteractionPathogenesisVirologyVirus ClassificationSingapore Grouper Iridovirus +5

Increased Frequency of ICOS+ CD4 T Cells as a Pharmacodynamic Biomarker for Anti-CTLA-4 Therapy

Derek Ng Tang, Yu Shen, Jingjing Sun, +5

Cancer Immunology Research

T-regulatory CellImmunologyImmunophenotypingCd4 T Cell ResponsesAnti-ctla-4 Therapy +14

Oleic acid induces apoptosis and autophagy in the treatment of Tongue Squamous cell carcinomas

Lin Jiang, Wei Wang, Qianting He, +5

Scientific Reports

Doxorubicin delivered by a redox-responsive dasatinib-containing polymeric prodrug carrier for combination therapy

Jingjing Sun, Yanhua Liu, Yichao Chen, +9

Journal of Controlled Release

Cell-based Drug DeliveryMedicinal ChemistryPolymer-drug ConjugateMedicinePharmacotherapy +4

miR-31-5p Is a Potential Circulating Biomarker and Therapeutic Target for Oral Cancer

Zhiyuan Lu, Qianting He, Jianfeng Liang, +13

Molecular Therapy — Nucleic Acids

Imperatorin Attenuates LPS-Induced Inflammation by Suppressing NF-κB and MAPKs Activation in RAW 264.7 Macrophages

Weixiao Guo, Jingjing Sun, Lanxiang Jiang, +7

Inflammation

InflammationMacrophage BiologyAnti-inflammatoryInflammatory DiseaseLps-induced Inflammation +10

N-acetylcysteine protects against liver injure induced by carbon tetrachloride via activation of the Nrf2/HO-1 pathway.

Zhaobin Cai, Qi Lou, Wang Fugen, +5

PubMed

Cell DeathRedox BiologyToxicological MechanismOxidative StressLiver Injure +19

Programmable co-delivery of the immune checkpoint inhibitor NLG919 and chemotherapeutic doxorubicin via a redox-responsive immunostimulatory polymeric prodrug carrier

Jingjing Sun, Yichao Chen, Yixian Huang, +5

Acta Pharmacologica Sinica