Single-cell transcriptomic analysis of Alzheimer’s disease

Hansruedi Mathys, José Dávila-Velderrain, Zhuyu Peng, +13

Nature

Neurodegenerative DiseasesMolecular NeuroscienceAlzheimer's DiseaseSingle Cell SequencingMedicine +5

Rare and low-frequency coding variants alter human adult height

Eirini Marouli, Mariaelisa Graff, Carolina Medina‐Gómez, +343

Nature

Allelic VariantGeneticsStatistical GeneticsVariant InterpretationHuman Adult Height

Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity

Valérie Turcot, Yingchang Lu, Heather M. Highland, +379

Nature Genetics

ObesityMetabolic SyndromeNutritionEnergy HomeostasisMetabolic Disorder +8

<i>APOE4</i> disrupts intracellular lipid homeostasis in human iPSC-derived glia

Grzegorz Sienski, Priyanka Narayan, Julia Maeve Bonner, +15

Science Translational Medicine

High-resolution genome-wide functional dissection of transcriptional regulatory regions and nucleotides in human

Xinchen Wang, Liang He, Sarah M. Goggin, +5

Nature Communications

NEBULA is a fast negative binomial mixed model for differential or co-expression analysis of large-scale multi-subject single-cell data

Liang He, José Dávila-Velderrain, Tomokazu S. Sumida, +3

Communications Biology

The trans-omics landscape of COVID-19

Peng Wu, Dongsheng Chen, Wencheng Ding, +67

Nature Communications

Virus EpidemiologyImmunologyCovid-19 EpidemiologyImmune DysregulationCovid-19 +15

Novel Reassortant Highly Pathogenic H5N2 Avian Influenza Viruses in Poultry in China

Guo Zhao, Xiaobing Gu, Xinlun Lu, +14

PLoS ONE

Novel InfluenzaDomestic PoultryViral EvolutionPoultry DiseasePathogenesis +7

Discovery of high-confidence human protein-coding genes and exons by whole-genome PhyloCSF helps elucidate 118 GWAS loci

Jonathan M. Mudge, Irwin Jungreis, Toby Hunt, +14

Genome Research

Comparative GenomicsGeneticsMolecular BiologyGene CharacterizationGenomics +19

Adaptation to chronic hypoxia involves immune cell invasion and increased expression of inflammatory cytokines in rat carotid body

X Liu, Liang He, L.J. Stensaas, +2

American Journal of Physiology-Lung Cellular and Molecular Physiology

Rat Carotid BodyImmunologyImmune RegulationOxidative StressInflammation +15