Single-cell transcriptomic analysis of Alzheimer’s disease

Hansruedi Mathys, José Dávila-Velderrain, Zhuyu Peng, +13

Nature

Neurodegenerative DiseasesMolecular NeuroscienceAlzheimer's DiseaseSingle Cell SequencingMedicine +5

APOE4 Causes Widespread Molecular and Cellular Alterations Associated with Alzheimer’s Disease Phenotypes in Human iPSC-Derived Brain Cell Types

Yuan-Ta Lin, Jinsoo Seo, Fan Gao, +18

Neuron

Cellular Alterations AssociatedNeurodegenerative DiseasesNeurobiology Of DiseaseMolecular NeuroscienceAlzheimer's Disease +12

Single-cell atlas reveals correlates of high cognitive function, dementia, and resilience to Alzheimer’s disease pathology

Hansruedi Mathys, Zhuyu Peng, Carles A. Boix, +27

Cell

Neuronal DNA double-strand breaks lead to genome structural variations and 3D genome disruption in neurodegeneration

Vishnu Dileep, Carles A. Boix, Hansruedi Mathys, +9

Cell

Revealing nanostructures in brain tissue via protein decrowding by iterative expansion microscopy

Deblina Sarkar, Jinyoung Kang, Asmamaw T. Wassie, +12

Nature Biomedical Engineering

NanomedicineTissue ImagingEngineeringMicroscopyNanobiotechnology +11

Expansion Revealing: Decrowding Proteins to Unmask Invisible Brain Nanostructures

Deblina Sarkar, Jinyoung Kang, Asmamaw T. Wassie, +9

Cerebral OrganoidNeurochemical BiomarkersCytoskeletonCellular NeurobiologySynaptic Signaling +19

Lateral mammillary body neurons in mouse brain are disproportionately vulnerable in Alzheimer’s disease

Wen‐Chin Huang, Zhuyu Peng, Mitchell H. Murdock, +12

Science Translational Medicine

Neurochemical BiomarkersAlzheimer ’Social SciencesMemory DeficitsNeurobiology Of Disease +17

Single-cell deconvolution of 3,000 post-mortem brain samples for eQTL and GWAS dissection in mental disorders

Yongjin Park, Liang He, José Dávila-Velderrain, +7

EngineeringGeneticsSingle-cell DeconvolutionBrain LesionMental Disorders +25