Cyclic immonium ion of lactyllysine reveals widespread lactylation in the human proteome

Ning Wan, Nian Wang, Siqin Yu, +15

Nature Methods

Proteomic TechnologyHuman ProteomeBiochemistryNatural SciencesCyclic Immonium Ion +3

Butyrate Suppresses the Proliferation of Colorectal Cancer Cells via Targeting Pyruvate Kinase M2 and Metabolic Reprogramming

Qingran Li, Lijuan Cao, Yang Tian, +9

Molecular & Cellular Proteomics

Comprehensive metabolomic profiling of nutrients in fish and shrimp

Chang Shao, Yang Su, Duanyue Meng, +4

Food Chemistry

Comprehensive Metabolomic ProfilingNutritionBiochemistryMetabolomic ProfilingMetabolic Profiling +3

p53 dynamics orchestrates with binding affinity to target genes for cell fate decision

Mengqiu Wu, Hui Ye, Zhiyuan Tang, +6

Cell Death and Disease

Chemoproteomic mapping of the glycolytic targetome in cancer cells

Yang Tian, Ning Wan, Hanqing Zhang, +10

Nature Chemical Biology

Tumor BiologyChemoproteomic MappingMedicineGlycobiologyCancer Genomics +5

Metabolomics–Proteomics Combined Approach Identifies Differential Metabolism-Associated Molecular Events between Senescence and Apoptosis

Mengqiu Wu, Hui Ye, Chang Shao, +10

Journal of Proteome Research

ApoptosisMetabolomic ProfilingCell DeathMetabolic RemodelingCancer Biology +15

Qing-Xin-Jie-Yu Granule alleviates atherosclerosis by reshaping gut microbiota and metabolic homeostasis of ApoE-/- mice

Anlu Wang, Baoyi Guan, Chang Shao, +7

Phytomedicine

InflammationMetabolic SyndromeLipid PeroxidationPhysiologyImmunology +11

Mitochondrial activity contributes to impaired renal metabolic homeostasis and renal pathology in STZ-induced diabetic mice

Mengqiu Wu, Shuzhen Li, Xiaowen Yu, +7

American Journal of Physiology-Renal Physiology

Mitochondrial ActivityRenal PathologyRenal InflammationMitochondrial BiologyInsulin Signaling +26

Cytosolic ME1 integrated with mitochondrial IDH2 supports tumor growth and metastasis

Chang Shao, Wenjie Lu, Ye Du, +6

Redox Biology

Reductive StressTumor BiologySystems BiologyMitochondrial FunctionMedicine +11

Living Cell-Target Responsive Accessibility Profiling Reveals Silibinin Targeting ACSL4 for Combating Ferroptosis

Wenchao Yan, Dexiang Wang, Ning Wan, +7

Analytical Chemistry

Molecular BiologyAcsl4 InhibitionSignaling PathwayAcsl4-mediated FerroptosisReceptor Tyrosine Kinase +14