Dianlin Xie

The Structure of Dasatinib (BMS-354825) Bound to Activated ABL Kinase Domain Elucidates Its Inhibitory Activity against Imatinib-Resistant ABL Mutants

John S. Tokarski, John A. Newitt, Chieh Ying J. Chang et al. · Cancer Research · 2006 · 686 citations · Full text

Medicine, Medicinal Chemistry, Oncology +13

Highly Selective Inhibition of Tyrosine Kinase 2 (TYK2) for the Treatment of Autoimmune Diseases: Discovery of the Allosteric Inhibitor BMS-986165

Stephen T. Wrobleski, Ryan Moslin, Shuqun Lin et al. · Journal of Medicinal Chemistry · 2019 · 369 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +15

Involvement of DPP‐IV catalytic residues in enzyme–saxagliptin complex formation

William J. Metzler, Joseph Yanchunas, Carolyn A. Weigelt et al. · Protein Science · 2008 · 128 citations · Full text

Life Sciences, Biochemistry, Pharmacology +17

Discovery of Pyrrolopyridine−Pyridone Based Inhibitors of Met Kinase: Synthesis, X-ray Crystallographic Analysis, and Biological Activities

Kyoung Soon Kim, Liping Zhang, Robert J. Schmidt et al. · Journal of Medicinal Chemistry · 2008 · 123 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +13

Tyrosine Kinase 2-mediated Signal Transduction in T Lymphocytes Is Blocked by Pharmacological Stabilization of Its Pseudokinase Domain

John S. Tokarski, Adriana Zupa-Fernandez, Jeffrey Tredup et al. · Journal of Biological Chemistry · 2015 · 116 citations · Full text

Life Sciences, Immunology, Pharmacology +17