Jeffrey Tredup

Highly Selective Inhibition of Tyrosine Kinase 2 (TYK2) for the Treatment of Autoimmune Diseases: Discovery of the Allosteric Inhibitor BMS-986165

Stephen T. Wrobleski, Ryan Moslin, Shuqun Lin et al. · Journal of Medicinal Chemistry · 2019 · 369 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +15

Tyrosine Kinase 2-mediated Signal Transduction in T Lymphocytes Is Blocked by Pharmacological Stabilization of Its Pseudokinase Domain

John S. Tokarski, Adriana Zupa-Fernandez, Jeffrey Tredup et al. · Journal of Biological Chemistry · 2015 · 116 citations · Full text

Life Sciences, Immunology, Pharmacology +17

2-Aryl-2,2-difluoroacetamide FKBP12 Ligands:  Synthesis and X-ray Structural Studies

Gene M. Dubowchik, Vivekananda M. Vrudhula, Bireshwar Dasgupta et al. · Organic Letters · 2001 · 104 citations

Pharmacy, Medicinal Chemistry, Pharmacology +11

Identification of <i>N</i>-Methyl Nicotinamide and <i>N</i>-Methyl Pyridazine-3-Carboxamide Pseudokinase Domain Ligands as Highly Selective Allosteric Inhibitors of Tyrosine Kinase 2 (TYK2)

Ryan Moslin, Yanlei Zhang, Stephen T. Wrobleski et al. · Journal of Medicinal Chemistry · 2019 · 92 citations · Full text

Life Sciences, Medicinal Chemistry, Pharmacology +17

Decrypting the Biochemical Function of an Essential Gene from Streptococcus pneumoniae Using ThermoFluor® Technology

Theodore E. Carver, Brian Bordeau, Maxwell D. Cummings et al. · Journal of Biological Chemistry · 2005 · 55 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +17