Zhongdong Zhao

Discovery of GS-9973, a Selective and Orally Efficacious Inhibitor of Spleen Tyrosine Kinase

Kevin Currie, Jeffrey E. Kropf, Tony Lee et al. · Journal of Medicinal Chemistry · 2014 · 167 citations · Full text

Orally Efficacious Inhibitor, Drug Target, Immunology +18

Directed <i>ortho</i> Metalation-Based Methodology. Halo-, Nitroso-, and Boro-Induced <i>ipso-</i>Desilylation. Link to an <i>in situ</i> Suzuki Reaction

Zhongdong Zhao, Victor Snieckus · Organic Letters · 2005 · 82 citations

Inorganic Chemistry, Chemical Engineering, Sequential Ipso-borodesilylation +14

Potent and selective Bruton’s tyrosine kinase inhibitors: Discovery of GDC-0834

Wendy B. Young, J A Barbosa, Peter Blomgren et al. · Bioorganic & Medicinal Chemistry Letters · 2015 · 64 citations · Full text

Molecular Pharmacology, Medicinal Chemistry, Biochemistry +11

Anionic Indole <i>N</i>-Carbamoyl N → C Translocation. A Directed remote Metalation Route to 2-Aryl- and 2-Heteroarylindoles. Synthesis of Benz[<i>a</i>]carbazoles and Indeno[1,2-<i>b</i>]indoles

Zhongdong Zhao, Ashley A. Jaworski, Isabel Piel et al. · Organic Letters · 2008 · 51 citations

Discovery of Lanraplenib (GS-9876): A Once-Daily Spleen Tyrosine Kinase Inhibitor for Autoimmune Diseases

Peter Blomgren, Jayaraman Chandrasekhar, Julie A. Di Paolo et al. · ACS Medicinal Chemistry Letters · 2020 · 49 citations · Full text

Translational Medicine, Autoimmune Disease, Medicine +15