Seth W. Grant

Discovery of 7-Methyl-5-(1-{[3-(trifluoromethyl)phenyl]acetyl}-2,3-dihydro-1<i>H</i>-indol-5-yl)-7<i>H</i>-pyrrolo[2,3-<i>d</i>]pyrimidin-4-amine (GSK2606414), a Potent and Selective First-in-Class Inhibitor of Protein Kinase R (PKR)-like Endoplasmic Reticulum Kinase (PERK)

Jeffrey M. Axten, Jesús R. Medina, Yanhong Feng et al. · Journal of Medicinal Chemistry · 2012 · 619 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +13

Identification of Potent, Selective, Cell-Active Inhibitors of the Histone Lysine Methyltransferase EZH2

Sharad K. Verma, Xinrong Tian, Louis V. LaFrance et al. · ACS Medicinal Chemistry Letters · 2012 · 376 citations · Full text

Life Sciences, Medicinal Chemistry, Molecular Biology +15

Discovery of GSK2656157: An Optimized PERK Inhibitor Selected for Preclinical Development

Jeffrey M. Axten, Stuart P. Romeril, Arthur Y. L. Shu et al. · ACS Medicinal Chemistry Letters · 2013 · 230 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +16

Structure-Based Design of Potent and Selective 3-Phosphoinositide-Dependent Kinase-1 (PDK1) Inhibitors

Jesús R. Medina, Christopher Becker, Charles W. Blackledge et al. · Journal of Medicinal Chemistry · 2011 · 54 citations · Full text

Pharmacy, Oncology, Pharmacology +13

Stereoselective Cascade Reactions that Incorporate a 7-<i>e</i><i>xo</i> Acyl Radical Cyclization

Seth W. Grant, Koudi Zhu, Yu Zhang et al. · Organic Letters · 2006 · 41 citations · Full text

Natural Sciences, Chemistry, Biocatalysis +12