Soluble TREM2 induces inflammatory responses and enhances microglial survival

Li Zhong, Xiao‐Fen Chen, Tingting Wang, +16

The Journal of Experimental Medicine

APOE4 exacerbates synapse loss and neurodegeneration in Alzheimer’s disease patient iPSC-derived cerebral organoids

Jing Zhao, Yuan Fu, Yu Yamazaki, +20

Nature Communications

TREM2 Promotes Microglial Survival by Activating Wnt/β-Catenin Pathway

Honghua Zheng, Lin Jia, Chia‐Chen Liu, +9

Journal of Neuroscience

LRP1 modulates the microglial immune response via regulation of JNK and NF-κB signaling pathways

Longyu Yang, Chia‐Chen Liu, Honghua Zheng, +9

Journal of Neuroinflammation

Peripheral apoE4 enhances Alzheimer’s pathology and impairs cognition by compromising cerebrovascular function

Chia‐Chen Liu, Jing Zhao, Yuan Fu, +37

Nature Neuroscience

Neurodegenerative DiseasesAlzheimer's DiseaseVascular DementiaDegenerative PathologyNeurology +7

Rod differentiation factor NRL activates the expression of nuclear receptor NR2E3 to suppress the development of cone photoreceptors

Edwin C. Oh, Hong Cheng, Hao Hong, +3

Brain Research

Photoreceptor CellMolecular PhysiologyDevelopmental BiologySignal TransductionSignaling Pathway +10

Deletion of autophagy inducer<i>RB1CC1</i>results in degeneration of the retinal pigment epithelium

Jingyu Yao, Lin Jia, Naheed W. Khan, +8

Autophagy

Cell-autonomous effects of APOE4 in restricting microglial response in brain homeostasis and Alzheimer’s disease

Chia‐Chen Liu, Na Wang, Yuanxin Chen, +26

Nature Immunology

Neurodegenerative DiseasesAlzheimer's DiseaseCell-autonomous EffectsMicroglial ResponseMedicine +10

Endometrial Glandular Dysplasia with Frequent p53 Gene Mutation: A Genetic Evidence Supporting Its Precancer Nature for Endometrial Serous Carcinoma

Lin Jia, Yongjuan Liu, Xiaofang Yi, +4

Clinical Cancer Research

Opposing roles of the triggering receptor expressed on myeloid cells 2 and triggering receptor expressed on myeloid cells-like transcript 2 in microglia activation

Honghua Zheng, Chia‐Chen Liu, Yuka Atagi, +11

Neurobiology of Aging

InflammationCytokineImmune Cell DevelopmentMedicineImmunology +9