APOE4 exacerbates synapse loss and neurodegeneration in Alzheimer’s disease patient iPSC-derived cerebral organoids

Jing Zhao, Yuan Fu, Yu Yamazaki, +20

Nature Communications

Alzheimer’s Risk Factors Age, APOE Genotype, and Sex Drive Distinct Molecular Pathways

Na Zhao, Yingxue Ren, Yu Yamazaki, +28

Neuron

Neurodegenerative DiseasesMolecular NeuroscienceAgingAlzheimer's DiseaseApoe Genotype +9

Vascular Cell Senescence Contributes to Blood–Brain Barrier Breakdown

Yu Yamazaki, Darren J. Baker, Masaya Tachibana, +5

Stroke

Selective loss of cortical endothelial tight junction proteins during Alzheimer’s disease progression

Yu Yamazaki, Mitsuru Shinohara, Motoko Shinohara, +10

Brain

Normal AgeingDisease ProgressionTight Junction ProteinsNeurochemical BiomarkersAlzheimer ’ +21

Treatment with SRT1720, a SIRT1 activator, ameliorates fatty liver with reduced expression of lipogenic enzymes in MSG mice

Yu Yamazaki, Isao Usui, Yukiko Kanatani, +14

American Journal of Physiology-Endocrinology and Metabolism

Sirt1 ActivatorSrt1720 TreatmentFatty Liver DiseaseCaloric RestrictionObesity +16

Peripheral apoE4 enhances Alzheimer’s pathology and impairs cognition by compromising cerebrovascular function

Chia‐Chen Liu, Jing Zhao, Yuan Fu, +37

Nature Neuroscience

Neurodegenerative DiseasesAlzheimer's DiseaseVascular DementiaDegenerative PathologyNeurology +7

ABCA7 Deficiency Accelerates Amyloid-β Generation and Alzheimer's Neuronal Pathology

Nobutaka Sakae, Chia‐Chen Liu, Mitsuru Shinohara, +21

Journal of Neuroscience

APOE4-mediated amyloid-β pathology depends on its neuronal receptor LRP1

Masaya Tachibana, Marie‐Louise Holm, Chia‐Chen Liu, +12

Journal of Clinical Investigation

Apoe GeneNeurochemical BiomarkersSynaptic SignalingSocial SciencesNeurobiology Of Disease +15

Modulation of Mitochondrial Complex I Activity Averts Cognitive Decline in Multiple Animal Models of Familial Alzheimer's Disease

Liang Zhang, Song Zhang, Izumi Maezawa, +17

EBioMedicine

Impact of sex and APOE4 on cerebral amyloid angiopathy in Alzheimer’s disease

Mitsuru Shinohara, Melissa E. Murray, Ryan D. Frank, +15

Acta Neuropathologica

Neurodegenerative DiseasesAlzheimer's DiseaseCerebral Amyloid AngiopathyMedicineVascular Dementia +7