Molecular subtyping of Alzheimer’s disease using RNA sequencing data reveals novel mechanisms and targets

Ryan Neff, Minghui Wang, Sezen Vatansever, +21

Science Advances

Ciliary transition zone activation of phosphorylated Tctex-1 controls ciliary resorption, S-phase entry and fate of neural progenitors

Aiqun Li, Masaki Saito, Jen Zen Chuang, +5

Nature Cell Biology

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Mitochondrial dysfunction and mitophagy defect triggered by heterozygous <i>GBA</i> mutations

Hongyu Li, Ahrom Ham, C. Thong, +10

Autophagy

Trispecific antibodies enhance the therapeutic efficacy of tumor-directed T cells through T cell receptor co-stimulation

Lan Wu, Edward Seung, Ling Xu, +32

Nature Cancer

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Neuron-specific signatures in the chromosomal connectome associated with schizophrenia risk

Prashanth Rajarajan, Tyler Borrman, Will Liao, +21

Science

Brain DevelopmentGeneticsEpigeneticsSocial SciencesPsychiatric Genetics +19

iPSC-Derived Dopamine Neurons Reveal Differences between Monozygotic Twins Discordant for Parkinson’s Disease

Chris M. Woodard, Brian A. Campos, Sheng‐Han Kuo, +18

Cell Reports

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Transformative Network Modeling of Multi-omics Data Reveals Detailed Circuits, Key Regulators, and Potential Therapeutics for Alzheimer’s Disease

Minghui Wang, Aiqun Li, Michiko Sekiya, +39

Neuron

Neurodegenerative DiseasesSystems BiologyAlzheimer's DiseasePotential TherapeuticsOmics Integration +11

MiR-30-Regulated Autophagy Mediates Angiotensin II-Induced Myocardial Hypertrophy

Wei Pan, Yun Zhong, Chuanfang Cheng, +5

PLoS ONE

Cardiac MuscleCardiomyopathyCell AutophagyMolecular PhysiologySurface Area +13

Trophic Factor Withdrawal: p38 Mitogen-Activated Protein Kinase Activates NHE1, Which Induces Intracellular Alkalinization

Annette R. Khaled, Andrea N. Moor, Aiqun Li, +6

Molecular and Cellular Biology

A trispecific antibody targeting HER2 and T cells inhibits breast cancer growth via CD4 cells

Edward Seung, Zhen Xing, Lan Wu, +25

Nature

Trispecific AntibodyBreast Cancer GrowthBreast OncologyImmunologyAntigen Processing +5