H3K9 methylation is a barrier during somatic cell reprogramming into iPSCs

Jiekai Chen, Liu He, Jing Liu, +17

Nature Genetics

ChromatinSomatic Cell GeneticsNatural SciencesEpigenetic ChangeDna Methylation +9

BMPs functionally replace Klf4 and support efficient reprogramming of mouse fibroblasts by Oct4 alone

Jiekai Chen, Jing Liu, Jiaqi Yang, +7

Cell Research

Knockout MouseBiomedical ResearchMedicineMolecular BiologyStem Cell Research +4

Intronic pentanucleotide TTTCA repeat insertion in the SAMD12 gene causes familial cortical myoclonic tremor with epilepsy type 1

Zhidong Cen, Zhengwen Jiang, You Chen, +21

Brain

Rational optimization of reprogramming culture conditions for the generation of induced pluripotent stem cells with ultra-high efficiency and fast kinetics

Jiekai Chen, Jing Liu, You Chen, +11

Cell Research

Tissue EngineeringRegenerative MedicineRational OptimizationInduced Pluripotent Stem CellEngineering +11

Floral display and breeding system of Jatropha curcas L.

Luo ChangWei, Kun Li, You Chen, +1

Forestry Studies in China

BiologyFloral DisplayBotanyPlant-insect InteractionNatural Sciences +1

Biallelic loss-of-function mutations in JAM2 cause primary familial brain calcification

Zhidong Cen, You Chen, Si Chen, +24

Brain

Developmental BiologyMendelian DisorderJam2 GeneMedicineGenetics +13

Diosmetin exhibits anti‐proliferative and anti‐inflammatory effects on TNF‐α‐stimulated human rheumatoid arthritis fibroblast‐like synoviocytes through regulating the Akt and NF‐κB signaling pathways

You Chen, Yongsheng Wang, Min Liu, +2

Phytotherapy Research

ImmunologyImmune RegulationPathologyCell DeathInflammatory Arthritis +19

Redox crisis underlies conditional light–dark lethality in cyanobacterial mutants that lack the circadian regulator, RpaA

Spencer Diamond, Benjamin E. Rubin, Ryan K. Shultzaberger, +3

Proceedings of the National Academy of Sciences

PhotobiologyMolecular BiologyMicrobial PhysiologyCyanobacteriaRedox Biology +17

Towards an Optimized Culture Medium for the Generation of Mouse Induced Pluripotent Stem Cells

Jiekai Chen, Jing Liu, Qingkai Han, +16

Journal of Biological Chemistry

Self-replicating shuttle vectors based on pANS, a small endogenous plasmid of the unicellular cyanobacterium Synechococcus elongatus PCC 7942

You Chen, Arnaud Taton, Michaela C. Go, +4

Microbiology

EngineeringBacteriologyEscherichia ColiCyanobacteriaBiosynthesis +15