Biallelic loss-of-function mutations in JAM2 cause primary familial brain calcification

Zhidong Cen, You Chen, Si Chen, +24

Brain

Developmental BiologyMendelian DisorderJam2 GeneMedicineGenetics +13

Protease-Activable Cell-Penetrating Peptide–Protoporphyrin Conjugate for Targeted Photodynamic Therapy in Vivo

Shiying Li, Hong Cheng, Wen‐Xiu Qiu, +6

ACS Applied Materials & Interfaces

NanomedicinePolycationic CppEngineeringDrug TargetingPolymer-drug Conjugate +13

Underestimated disease prevalence and severe phenotypes in patients with biallelic variants: A cohort study of primary familial brain calcification from China

Si Chen, Zhidong Cen, Feng Fu, +63

Parkinsonism & Related Disorders

Biallelic VariantsGenetic DisorderDisease PrevalenceGenetic EpidemiologySevere Phenotypes +7

Loss of E-cadherin is causal to pathologic changes in chronic lung disease

Baishakhi Ghosh, Jeffrey Loube, Shreeti Thapa, +19

Communications Biology

Evaluation of <i>MYORG</i> mutations as a novel cause of primary familial brain calcification

You Chen, Feng Fu, Si Chen, +12

Movement Disorders

NOGO-B promotes EMT in lung fibrosis via MMP14 mediates free TGF-beta1 formation

Ye Xiong, Jing Zhang, Lingzhi Shi, +7

Oncotarget

InflammationFibrosisEmt AbilityInflammatory Lung DiseaseLung Inflammation +11

Vascular smooth muscle RhoA counteracts abdominal aortic aneurysm formation by modulating MAP4K4 activity

Md Rasel Molla, Akio Shimizu, Masahiro Komeno, +12

Communications Biology

<i>MYORG</i> Mutation Heterozygosity Is Associated With Brain Calcification

You Chen, Zhidong Cen, Xinhui Chen, +29

Movement Disorders

Silica Perturbs Primary Cilia and Causes Myofibroblast Differentiation during Silicosis by Reduction of the KIF3A-Repressor GLI3 Complex

Shifeng Li, Zhongqiu Wei, Gengxu Li, +13

Theranostics

Matrix stiffness regulates α-TAT1-mediated acetylation of α-tubulin and promotes silica-induced epithelial–mesenchymal transition via DNA damage

Gengxu Li, Si Chen, Yi Zhang, +11

Journal of Cell Science