Intrinsic BET inhibitor resistance in SPOP-mutated prostate cancer is mediated by BET protein stabilization and AKT–mTORC1 activation

Pingzhao Zhang, Dejie Wang, Yu Zhao, +23

Nature Medicine

Bet Protein StabilizationMedicineCancer Cell BiologySpop-mutated Prostate CancerCell Biology +7

Prostate Cancer-associated SPOP mutations enhance cancer cell survival and docetaxel resistance by upregulating Caprin1-dependent stress granule assembly

Qing Shi, Yasheng Zhu, Jian Ma, +18

Molecular Cancer

The Ubiquitin Ligase Itch Regulates Apoptosis by Targeting Thioredoxin-interacting Protein for Ubiquitin-dependent Degradation

Pingzhao Zhang, Chenji Wang, Kun Gao, +8

Journal of Biological Chemistry

Reductive StressMitophagyProtein FunctionSignal TransductionThioredoxin-interacting Protein +9

Exosomes Derived From Septic Mouse Serum Modulate Immune Responses via Exosome-Associated Cytokines

Kun Gao, Jingmiao Jin, Chenyang Huang, +5

Frontiers in Immunology

Serum ExosomesInnate Immune SystemImmunologyImmunologic MechanismExtracellular Microvesicles +15

Dysregulation of INF2-mediated mitochondrial fission in SPOP-mutated prostate cancer

Xiaofeng Jin, Jie Wang, Kun Gao, +15

PLoS Genetics

The Nedd4-like ubiquitin E3 ligases target angiomotin/p130 to ubiquitin-dependent degradation

Chenji Wang, An Jian, Pingzhao Zhang, +7

Biochemical Journal

Ubiquitin E3 LigasesAngiogenesisDevelopmental BiologySignal TransductionSignaling Pathway +13

Endometrial cancer-associated mutants of SPOP are defective in regulating estrogen receptor-α protein turnover

Peng Zhang, Kun Gao, Xiaofeng Jin, +10

Cell Death and Disease

SPOP mutation induces DNA methylation via stabilizing GLP/G9a

Jianong Zhang, Kun Gao, Hongyan Xie, +19

Nature Communications

SPOP promotes ATF2 ubiquitination and degradation to suppress prostate cancer progression

Jian Ma, Kun Chang, Jingtao Peng, +16

Journal of Experimental & Clinical Cancer Research

CRL3–SPOP ubiquitin ligase complex suppresses the growth of diffuse large B-cell lymphoma by negatively regulating the MyD88/NF-κB signaling

Xiaofeng Jin, Qing Shi, Qian Li, +28

Leukemia

Tumor BiologyLymphoid NeoplasiaCell RegulationMyd88/nf-κb SignalingImmune Cell Development +10