Guangming Chen

PTC124 targets genetic disorders caused by nonsense mutations

Ellen Welch, Elisabeth R. Barton, Jin Zhuo et al. · Nature · 2007 · 1.1K citations

Life Sciences, Genetics, Molecular Genetics +8

<i>SMN2</i> splicing modifiers improve motor function and longevity in mice with spinal muscular atrophy

Nikolai A. Naryshkin, Marla Weetall, Amal Dakka et al. · Science · 2014 · 526 citations

Life Sciences, Molecular Biology, Neuroscience +17

Discovery and Optimization of Small Molecule Splicing Modifiers of Survival Motor Neuron 2 as a Treatment for Spinal Muscular Atrophy

Matthew G. Woll, Hongyan Qi, Anthony Turpoff et al. · Journal of Medicinal Chemistry · 2016 · 61 citations

Life Sciences, Medicinal Chemistry, Neuroscience +13

A pilot randomized controlled trial of dual‐plasmid HBV DNA vaccine mediated by <i>in vivo</i> electroporation in chronic hepatitis B patients under lamivudine chemotherapy

Fuqiang Yang, Yeping Yu, G.‐Q. Wang et al. · Journal of Viral Hepatitis · 2012 · 54 citations

Veterinary Medicine, Immunology, Infectious Diseases +17

Structure–Activity Relationship (SAR) Optimization of 6-(Indol-2-yl)pyridine-3-sulfonamides: Identification of Potent, Selective, and Orally Bioavailable Small Molecules Targeting Hepatitis C (HCV) NS4B

Nanjing Zhang, Xiaoyan Zhang, Jin Zhu et al. · Journal of Medicinal Chemistry · 2013 · 43 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17