Chang Shu

Cyclic GMP-AMP Synthase Is Activated by Double-Stranded DNA-Induced Oligomerization

Xin Li, Chang Shu, Guanghui Yi et al. · Immunity · 2013 · 627 citations · Full text

Natural Sciences, Oligonucleotide, Dna Replication +2

A conserved PLPLRT/SD motif of STING mediates the recruitment and activation of TBK1

Baoyu Zhao, Fenglei Du, Pengbiao Xu et al. · Nature · 2019 · 394 citations · Full text

Transcriptional Regulation, Signal Transduction, Signaling Pathway +9

Structure of STING bound to cyclic di-GMP reveals the mechanism of cyclic dinucleotide recognition by the immune system

Chang Shu, Guanghui Yi, Tylan Watts et al. · Nature Structural & Molecular Biology · 2012 · 292 citations

Signal Transduction, G Protein-coupled Receptor, Innate Immune System +10

Single Nucleotide Polymorphisms of Human STING Can Affect Innate Immune Response to Cyclic Dinucleotides

Guanghui Yi, Volker Brendel, Chang Shu et al. · PLoS ONE · 2013 · 254 citations · Full text

Antitumor Activity of cGAMP via Stimulation of cGAS-cGAMP-STING-IRF3 Mediated Innate Immune Response

Tiejun Li, Hao Cheng, Hong Yuan et al. · Scientific Reports · 2016 · 248 citations · Full text