A conserved PLPLRT/SD motif of STING mediates the recruitment and activation of TBK1

Baoyu Zhao, Fenglei Du, Pengbiao Xu, +15

Nature

Transcriptional RegulationSignal TransductionSignaling PathwayCell RegulationNatural Sciences +7

Mitochondrial ROS promotes susceptibility to infection via gasdermin D-mediated necroptosis

Chi G. Weindel, E. Martínez, Xiao Zhao, +14

Cell

InflammationMitophagyMitochondrial FunctionPathogenesisPathology +6

The molecular basis of tight nuclear tethering and inactivation of cGAS

Baoyu Zhao, Pengbiao Xu, Chesley Marie Rowlett, +6

Nature

Molecular BiologyPhysical ChemistryMolecular BasisTight Nuclear TetheringBiophysics

NONO Detects the Nuclear HIV Capsid to Promote cGAS-Mediated Innate Immune Activation

Xavier Lahaye, Matteo Gentili, Aymeric Silvin, +17

Cell

Primary ImmunodeficiencyNuclear Hiv CapsidHuman RetrovirusInnate Immune SystemImmunology +6

Structure and function of the Zika virus full-length NS5 protein

Baoyu Zhao, Guanghui Yi, Fenglei Du, +5

Nature Communications

Structural basis for concerted recruitment and activation of IRF-3 by innate immune adaptor proteins

Baoyu Zhao, Chang Shu, Xinsheng Gao, +6

Proceedings of the National Academy of Sciences

SWI2/SNF2 ATPase CHR2 remodels pri-miRNAs via Serrate to impede miRNA production

Zhiye Wang, Zeyang Ma, Claudia Castillo-González, +6

Nature

BiologyNatural SciencesProtein BiosynthesisRna BiologyMolecular Biology +8

A Quick Route to Multiple Highly Potent SARS‐CoV‐2 Main Protease Inhibitors**

Kai S. Yang, R. Xinyu, Yuying Ma, +19

ChemMedChem

The deubiquitinase Otub1 controls the activation of CD8+ T cells and NK cells by regulating IL-15-mediated priming

Xiaofei Zhou, Jiayi Yu, Xuhong Cheng, +7

Nature Immunology

Autoimmune DiseaseImmune Cell DevelopmentMedicineT-regulatory CellImmunology +9

Oligoadenylate-Synthetase-Family Protein OASL Inhibits Activity of the DNA Sensor cGAS during DNA Virus Infection to Limit Interferon Production

Arundhati Ghosh, Lulu Shao, Padmavathi Sampath, +12

Immunity

Viral ReplicationBiochemistryNatural SciencesOligonucleotideMolecular Biology +7