Discovery of AMG 232, a Potent, Selective, and Orally Bioavailable MDM2–p53 Inhibitor in Clinical Development

Daqing Sun, Zhihong Li, Yosup Rew, +46

Journal of Medicinal Chemistry

A novel autophagy/mitophagy inhibitor liensinine sensitizes breast cancer cells to chemotherapy through DNM1L-mediated mitochondrial fission

Jing Zhou, Guobing� Li, Yi Zheng, +6

Autophagy

MitophagyChemoprevention StrategyApoptosisCell DeathDnm1l-mediated Mitochondrial Fission +18

Structure-Based Design of Novel Inhibitors of the MDM2–p53 Interaction

Yosup Rew, Daqing Sun, Felix González-López de Turiso, +32

Journal of Medicinal Chemistry

Spectroscopic Studies of Substrate Interactions with Clavaminate Synthase 2, a Multifunctional α-KG-Dependent Non-Heme Iron Enzyme:  Correlation with Mechanisms and Reactivities

Jing Zhou, Wendy L. Kelly, Brian O. Bachmann, +3

Journal of the American Chemical Society

Clavaminate Synthase 2Substrate InteractionsBiosynthesisAldo-keto ReductaseBiochemistry +13

Circular Dichroism and Magnetic Circular Dichroism Spectroscopic Studies of the Non-Heme Ferrous Active Site in Clavaminate Synthase and Its Interaction with α-Ketoglutarate Cosubstrate

Elizabeth G. Pavel, Jing Zhou, Robert Busby, +3

Journal of the American Chemical Society

BiosynthesisBioorganic ChemistryClavaminate SynthaseBiochemistryα-Ketoglutarate Cosubstrate +10

The MDM2 Inhibitor AMG 232 Demonstrates Robust Antitumor Efficacy and Potentiates the Activity of p53-Inducing Cytotoxic Agents

Jude Canon, Tao Osgood, Steven H. Olson, +14

Molecular Cancer Therapeutics

Amg 232Tumor BiologyP53-inducing Cytotoxic AgentsMdm2-p53 InteractionMedicine +11

Establishment of Clonal Colony-Forming Assay for Propagation of Pancreatic Cancer Cells With Stem Cell Properties

Shanmiao Gou, Tao Liu, Chunyou Wang, +3

Pancreas

An expanded benchmark for antibody-antigen docking and affinity prediction reveals insights into antibody recognition determinants

Johnathan D. Guest, Thom Vreven, Jing Zhou, +5

Structure

Molecular DockingImmunocytochemical TechniqueImmunotherapyMedicineNatural Sciences +12

A human CD137×PD-L1 bispecific antibody promotes anti-tumor immunity via context-dependent T cell costimulation and checkpoint blockade

Cecile Geuijen, Paul J. Tacken, Liang-Chuan Wang, +38

Nature Communications

Persistence of side population cells with high drug efflux capacity in pancreatic cancer

Jing Zhou

World Journal of Gastroenterology